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West Nile Virus (WNV)

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By Targets:	Virus Protease (7) Apoptosis (4) Aurora Kinase (4) Autophagy (2) Bacterial (4) HIV (2) Indoleamine 2,3-Dioxygenase (IDO) (4) mAChR (4) Parasite (4)
By Research Areas:	Cancer (4) Infection (9) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (4)

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Recombinant Proteins

Targets Recommended: Influenza Virus Dengue virus Virus Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Flaviviruses-IN-3	Virus Protease	Infection
Flaviviruses-IN-3 (compound 87) is a potent flaviviruse inhibitor. Flaviviruses-IN-3 reduces the *WNV* (West Nile virus) protease activity, with a inhibition of 54% .

Tat-beclin 1 1 Publications Verification	Autophagy HIV	Infection
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

SID-852843	Virus Protease	Infection
SID-852843 is a WNV NS2B-NS3 proteinase inhibitor. SID-852843 can inhibit WNV NS2B-NS3 proteinase activity with IC₅₀ value of 0.105 μM. SID-852843 can be used for the research of virus infection .

Palmatine chloride Maximum Cited Publications 6 Publications Verification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Palmatine hydroxide Maximum Cited Publications 6 Publications Verification	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Flaviviruses-IN-2	Virus Protease	Infection
Flaviviruses-IN-2 (compound 78) is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces the *WNV* (West Nile virus) protease activity, with inhibition of 56% .

Tat-beclin 1 TFA	Autophagy HIV	Infection
Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

Palmatine	mAChR Indoleamine 2,3-Dioxygenase (IDO) Virus Protease Aurora Kinase Apoptosis Bacterial Parasite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Palmatine chloride (Standard)	Apoptosis Virus Protease Indoleamine 2,3-Dioxygenase (IDO) Parasite Bacterial Aurora Kinase mAChR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Palmatine (chloride) (Standard) is the analytical standard of Palmatine (chloride). This product is intended for research and analytical applications. Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities .

Cat. No.	Product Name	Target	Research Area

Tat-beclin 1 1 Publications Verification	Autophagy HIV	Infection
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

Boc-GRR-AMC	Peptides	Others
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

Boc-GRR-AMC TFA	Peptides	Others
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .

Tat-beclin 1 TFA	Autophagy HIV	Infection
Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

Species:	Virus (5)
Tag:	His (5)
Source:	HEK293 (1) P. pastoris (4)

Cat. No.	Compare	Product Name	Species	Source

	West Nile Virus NS1 Protein (HEK293, His) West Nile Virus (WNV) (lineage 1, strain NY99) NS1 Protein	Virus	HEK293
	West Nile Virus NS1 Protein is a glycoprotein among the flavivirus genus. It is found in both membrane-associated and soluble secreted forms. WNV NS1 has an unusual structure-function because it is glycosylated and forms different structures to facilitate different roles intracellularly and extracellularly, including roles in the replication complex, assisting in virus assembly, and complement antagonism. It also plays a role in protective immunity through antibody-mediated cellular cytotoxicity, and anti-NS1 antibodies elicit passive protection in animal models against a virus challenge. West Nile Virus NS1 Protein (HEK293, His) is the recombinant Virus-derived West Nile Virus NS1 protein, expressed by HEK293 , with N-His labeled tag.

	E/Envelope Protein, West Nile Virus Lineage 2 (120a.a, P.pastoris, His) WNV-E Protein, WNV	Virus	P. pastoris
	E/Envelope Protein, West Nile Virus Lineage 2 (120a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris , with C-His labeled tag. The total length of E/Envelope Protein, West Nile Virus Lineage 2 (120a.a, P.pastoris, His) is 120 a.a., with molecular weight of ~14 kDa.

	E/Envelope Protein, West Nile Virus Lineage 2 (109a.a, P.pastoris, His) WNV-E Protein, WNV	Virus	P. pastoris
	E/Envelope Protein, West Nile Virus Lineage 2 (109a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris , with C-His labeled tag. The total length of E/Envelope Protein, West Nile Virus Lineage 2 (109a.a, P.pastoris, His) is 109 a.a., with molecular weight of ~12.9 kDa.

	E/Envelope Protein, West Nile virus Lineage 1 (120a.a, P.pastoris, His) WNV-E Protein, WNV	Virus	P. pastoris
	E/Envelope Protein, West Nile virus Lineage 1 (120a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris , with C-His labeled tag. The total length of E/Envelope Protein, West Nile virus Lineage 1 (120a.a, P.pastoris, His) is 120 a.a., with molecular weight of ~14 kDa.

	E/Envelope Protein, West Nile Virus Lineage 1 (109a.a, P.pastoris, His) WNV-E Protein, WNV	Virus	P. pastoris
	E/Envelope Protein, West Nile Virus Lineage 1 (109a.a, P.pastoris, His) is the recombinant Virus-derived E/Envelope protein, expressed by P. pastoris , with C-His labeled tag. The total length of E/Envelope Protein, West Nile Virus Lineage 1 (109a.a, P.pastoris, His) is 109 a.a., with molecular weight of ~12.9 kDa.

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