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Results for "

ceramidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ceramidase (10) Apoptosis (2) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (1) FAAH (2) Fluorescent Dye (2) Fungal (1) Glucosylceramide Synthase (GCS) (1) Glutathione Peroxidase (2) iGluR (1) LPL Receptor (2) Nucleoside Antimetabolite/Analog (2) PARP (1) Phospholipase (2) SARS-CoV (2) Virus Protease (2)
By Research Areas:	Cancer (14) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dye

Recombinant Proteins

Targets Recommended: Ceramidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153396

*Acid Ceramidase-IN-2*	Ceramidase	Cancer
Acid Ceramidase-IN-2 (compound 1) is an acid *ceramidase* inhibitor with potentially antiproliferative and cytostatic activities. Moreover, human acid ceramidase is overexpressed in prostate cancer cells, indicating potential anti-tumor effect of Acid Ceramidase-IN-2. And Acid Ceramidase-IN-2 hydrolysis can be inhibited by 3 a-ketoamides GT85, GT98 and GT99 inhibits in vitro .

HY-141866

*Acid Ceramidase-IN-1*	Ceramidase	Neurological Disease
Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC₅₀=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice .

HY-103359

Ceranib1	Ceramidase	Cancer
Ceranib1 is a *ceramidase* inhibitor. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. Ceranib1 inhibits the proliferation of ovarian cancer cells .

HY-129411

Sinbaglustat ACT-519276; OGT2378	Glucosylceramide Synthase (GCS)	Metabolic Disease
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions .

HY-103593A

LCL521 dihydrochloride 1 Publications Verification	Phospholipase	Cancer
LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) .

HY-141577

C12-NBD Sphinganine	Biochemical Assay Reagents	Others
C12-NBD Sphinganine is a fluorescent *ceramidase* substrate. C12-NBD Sphinganine can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources .

HY-141575

C12-NBD-ceramide	Fluorescent Dye	Others
C12-NBD-ceramide is a fluorescent analogue of ceramide, it can be used as a substrate in ceramidase assays .

HY-163106

W000113414_I13	Ceramidase	Cancer
W000113414_I13 is an acid ceramidase (AC) inhibitor. W000113414_I13 exhibits dose-dependent inhibition of AC with an IC₅₀ value of 6.6?μM. W000113414_I13 can be used for the research of cancer .

HY-124962

D-NMAPPD (1R,2R)-B13	iGluR	Neurological Disease Cancer
D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs .

HY-158783

SACLAC	Ceramidase Bcl-2 Family LPL Receptor Apoptosis	Neurological Disease
SACLAC, a Ceramide analog, is a potent and covalent *acid ceramidase* (ASAH1; AC) inhibitor with a K_i of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis** in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models .

HY-103593

LCL521 1 Publications Verification	Phospholipase	Cancer
LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase) .

HY-137422

D-erythro-MAPP 1 Publications Verification D-e-MAPP	Ceramidase	Neurological Disease Cancer
D-erythro-MAPP (D-e-MAPP) is a *ceramidase* inhibitor, with an IC₅₀ of 1-5 μM in vitro .

HY-124927

ARN14988	Others	Cancer
ARN14988 is a potent inhibitor of *acid ceramidase* (ACDase) (IC₅₀**=12.8 nM for the human enzyme) .

HY-116147

Ceranib-2	LPL Receptor Apoptosis	Cancer
Ceranib-2 is a potent and nonlipid *ceramidase* inhibitor that inhibits cellular *ceramidase* activity with an IC₅₀ of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity .

HY-103592

ARN14974	Ceramidase	Cancer
ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC₅₀=79 nM) .

HY-D1582

C12 NBD Phytoceramide	Fluorescent Dye	Others
C12 NBD Phytoceramide, a ceramide analogue, is a fluorescent substrate, can be used to detect ceramidase activity .

HY-W414498

1-Deoxysphingosine	Others	Neurological Disease
1-Deoxysphingosine is elevated in lymphoblasts of individuals with hereditary sensory neuropathy type 1 (HSAN1) disorder; it features a (4E) double bond in its structure and is produced through the catabolism of 1-deoxyceramide catalyzed by the ceramidase enzyme, classifying it as an unsaturated deoxy-sphingoid base.

HY-124134

AD-2646 LCL102	Ceramidase Caspase PARP	Cancer
AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC₅₀: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a *ceramidase* inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism .

HY-B0182

Carmofur 3 Publications Verification HCFU	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-B0182R

Carmofur (Standard)	Nucleoside Antimetabolite/Analog SARS-CoV Virus Protease FAAH Ceramidase Glutathione Peroxidase	Infection Inflammation/Immunology Cancer
Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC₅₀ of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) .

HY-139062

C6 Urea Ceramide C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea; D-erythro-Urea-C6-Ceramide	Others	Cancer
C6 Urea Ceramide (C6 Ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea) is an inhibitor of neutral ceramidase. It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and HT-29 colon cancer cells, but not in MEFs lacking neutral ceramidase. At concentrations of 5 and 10 μM, it inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but not in noncancerous RIE-1 cells. C6 Urea Ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116 cells, but not in RIE-1 cells. When administered at doses of 1.25, 2.5, and 5 mg/kg for five days, it reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.

HY-168066

Antifungal agent 117	Fungal	Infection
Antifungal agent 117 is a bis-pyrazole carboxamide derivative with antifungal activity, exhibiting an EC₅₀ value of 11.58 mg/L against Sclerotinia sclerotiorum. Antifungal agent 117 increases cell membrane permeability, causing an imbalance in osmotic pressure inside and outside the cell, and induces the accumulation of reactive oxygen species (ROS), leading to oxidative damage to the cell membrane, resulting in leakage of cellular contents and eventually cell death. RNA sequencing analysis reveals that Antifungal agent 117 downregulates catalase genes and upregulates neutral ceramidase genes, disrupting cell membrane structure, accelerating sphingolipid metabolism, and promoting cell death. Antifungal agent 117 shows great potential in the fields of plant protection and antifungal infection .

Cat. No.	Product Name	Type

HY-141577

C12-NBD Sphinganine	Dyes
C12-NBD Sphinganine is a fluorescent *ceramidase* substrate. C12-NBD Sphinganine can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources .

HY-141575

C12-NBD-ceramide	Fluorescent Dyes/Probes
C12-NBD-ceramide is a fluorescent analogue of ceramide, it can be used as a substrate in ceramidase assays .

HY-D1582

C12 NBD Phytoceramide	Chromogenic Substrates
C12 NBD Phytoceramide, a ceramide analogue, is a fluorescent substrate, can be used to detect ceramidase activity .

Species:	Human (1) Mouse (1)
Tag:	SUMO (1) His (2)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71541

	ASAH1 Protein, Human (His-SUMO) AC; ACDase; Acid CDase; Acid ceramidase; Acid ceramidase precursor; Acid ceramidase subunit beta; Acylsphingosine deacylase; ASAH 1; ASAH; ASAH1; ASAH1_HUMAN; FLJ21558; FLJ22079; N acylsphingosine amidohydrolase (acid ceramidase) 1; N acylsphingosine amidohydrolase 1	Human	E. coli
	ASAH1 is a lysosomal ceramidase that critically regulates sphingolipid metabolism by hydrolyzing ceramide into sphingosine and fatty acids at acidic pH. Bioactive lipids—ceramide, sphingosine, and sphingosine-1-phosphate—control signaling pathways for cell proliferation, apoptosis, and differentiation. ASAH1 Protein, Human (His-SUMO) is the recombinant human-derived ASAH1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of ASAH1 Protein, Human (His-SUMO) is 374 a.a., with molecular weight of ~58.7 kDa.

HY-P76735

	ASAH2 Protein, Mouse (HEK293, His) 1 Publications Verification Neutral ceramidase; N-Cdase; Acylsphingosine deacylase 2	Mouse	HEK293
	ASAH2 protein has N-acylsphingosine amide hydrolase activity, which is essential for lipid digestion and sphingolipid metabolism. It is present in different cellular compartments, highlighting its versatility. ASAH2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ASAH2 protein, expressed by HEK293 , with N-His labeled tag.

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