2. Metabolic Enzyme/Protease GPCR/G Protein Apoptosis
  3. Ceramidase Bcl-2 Family LPL Receptor Apoptosis
  4. SACLAC

SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models.

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SACLAC Chemical Structure

SACLAC Chemical Structure

CAS No. : 2248703-42-4

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SACLAC Related Antibodies

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Description

SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models[1][2].

Molecular Weight

377.99

Formula

C20H40ClNO3
CAS No.
SMILES

CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(CCl)=O
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Purity & Documentation
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SACLAC Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SACLAC2248703-42-4CeramidaseBcl-2 FamilyLPL ReceptorApoptosisLysophospholipid ReceptorCovalentacid ceramidaseASAH1ACsphingosine 1-phosphateceramideSF3B1Mcl-1Mcl-1Sacute myeloid leukemiaAMLInhibitorinhibitorinhibit

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