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receptor-interacting kinase 1 (RIPK1)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RIP kinase (9) Necroptosis (2) Ser/Thr Protease (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (9) Neurological Disease (4)

11

Inhibitors & Agonists

7

Recombinant Proteins

Targets Recommended: MNK RIP kinase PIN1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Eclitasertib DNL-758; SAR-443122	RIP kinase	Inflammation/Immunology
Eclitasertib (DNL-758) is a potent **receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC₅₀** of <1 µΜ (From patent WO2017136727A2, example 42) .

RI-962	RIP kinase Necroptosis	Neurological Disease Inflammation/Immunology
RI-962 is a potent and selective **receptor-interacting protein kinase 1 (RIPK1)** inhibitor. RI-962 inhibits RIPK1 with an IC₅₀ value of 35.0 nM. RI-962 can be used for the research of nervous system diseases and inflammatory diseases .

PK68	RIP kinase	Inflammation/Immunology Cancer
PK68 is a potent orally active and specifical type II inhibitor of **receptor-interacting kinase 1 (RIPK1) with an IC₅₀** of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis .

GSK547 GSK'547	RIP kinase	Cancer
GSK547 (GSK'547) is a highly selective and potent inhibitor of **receptor-interacting serine/threonine protein kinase 1 (RIPK1)**, inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer .

Oditrasertib SAR443820; DNL788	RIP kinase	Neurological Disease Inflammation/Immunology
Oditrasertib (SAR443820) is an orally active and brain-penetrant receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC₅₀ value lower than 100 nM. Oditrasertib could make nerve cells more resistant to the pathology and slow down the disease. Oditrasertib can be used for the research of neurodegenerative diseases involving inflammation or cell death .

Ocadusertib LY3871801; R 552	RIP kinase	Inflammation/Immunology
Ocadusertib is a potent Serine/Threonine kinase receptor-interacting protein kinase 1 (RIPK1) inhibitor .

RIPK1-IN-24	Others	Inflammation/Immunology
RIPK1-IN-24 is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC₅₀ value of 1.3 μM. RIPK1-IN-24 can be used for research on inflammatory diseases .

RIPK1-IN-22	RIP kinase	Inflammation/Immunology
RIPK1-IN-13 (compound 28) is a selective inhibitor for receptor-interacting serine/threonine-protein kinase 1 (RIPK1), the inhibitory activity is measured by ADP-Glo Kinase Assay with a pK_i of 7.66. RIPK1-IN-13 inhibits human leukaemia cells U937 with a pIC₅₀ of 7.2 .

RIPK1-IN-26	Ser/Thr Protease	Neurological Disease
RIPK1-IN-26 (Compound 8a) is a potent receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor with cell anti-necroptosis potency. RIPK1-IN-26 demonstrats good metabolic stability and good binding specificity in mice. RIPK1-IN-26 is promising for research of PET imaging probe development and neurodegenerative disorders .

Necroptosis-IN-5	Necroptosis RIP kinase	Neurological Disease Inflammation/Immunology Cancer
Necroptosis-IN-5 (Compound 26) is an orally active necroptosis inhibitor. Necroptosis-IN-5 also exhibits potent inhibitory activity against **receptor-interacting protein kinase 1 (RIPK1)**. Necroptosis-IN-5 can be used to study necroptosis-related inflammatory diseases, neurodegenerative diseases, and cancers .

RIPK1-IN-4	RIP kinase	Inflammation/Immunology
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC₅₀s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase .

Species:	Human (1) Mouse (1) Rat (1) Cynomolgus (2) Dog (1) Canine (1)
Tag:	His (2) GST (6)
Source:	Sf9 insect cells (6) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	RIPK1 Protein, Human (Sf9, His, GST) RIPK1; receptor-interacting serine/threonine-protein kinase 1; Cell death protein RIP; receptor-interacting protein 1; RIP-1	Human	Sf9 insect cells
	RIPK1 protein is a serine-threonine kinase that centrally regulates TNF-mediated apoptosis, necroptosis, and inflammatory pathways. Functionally, it plays a kinase-dependent role in the regulation of cell death and a kinase-independent scaffolding function in the control of inflammatory signaling and cell survival. RIPK1 Protein, Human (Sf9, His, GST) is the recombinant human-derived RIPK1 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of RIPK1 Protein, Human (Sf9, His, GST) is 327 a.a., .

	RIPK1 Protein, Mouse (His) Ripk1; Rinp; Rip; receptor-interacting serine/threonine-protein kinase 1; EC 2.7.11.1; Cell death protein RIP; receptor-interacting protein 1; RIP-1	Mouse	E. coli
	RIPK1 protein is a serine-threonine kinase that centrally regulates TNF-mediated apoptosis, necroptosis, and inflammatory pathways. Functionally, it plays a kinase-dependent role in the regulation of cell death and a kinase-independent scaffolding function in the control of inflammatory signaling and cell survival.

	RIPK1 Protein, Cynomolgus (sf9, GST) receptor interacting serine/threonine kinase 1; RIPK1	Cynomolgus	Sf9 insect cells
	RIPK1 Protein, Cynomolgus (sf9, GST) is the recombinant cynomolgus-derived RIPK1, expressed by Sf9 insect cells , with N-GST labeled tag. ,

	RIPK1 Protein, Canine (sf9, GST) receptor interacting serine/threonine kinase 1; RIPK1	Canine	Sf9 insect cells
	RIPK1 Protein, Canine (sf9, GST) is the recombinant canine-derived RIPK1, expressed by Sf9 insect cells , with N-GST labeled tag. ,

	RIPK1 Protein, Rat (sf9, GST) receptor interacting serine/threonine kinase 1 Imported; Ripk1	Rat	Sf9 insect cells
	RIPK1 Protein, Rat (sf9, GST) is the recombinant rat-derived RIPK1, expressed by Sf9 insect cells , with N-GST labeled tag. ,

	RIPK1 Protein,Cynomolgus (Active, sf9, GST) receptor interacting serine/threonine kinase 1; RIPK1	Cynomolgus	Sf9 insect cells
	RIPK1 Protein,Cynomolgus (Active, sf9, GST) is the recombinant cynomolgus-derived RIPK1, expressed by Sf9 insect cells , with GST labeled tag. ,

	RIPK1 Protein, Dog (Active, 1-327, sf9, GST) receptor interacting serine/threonine kinase 1; RIPK1	Dog	Sf9 insect cells
	RIPK1 Protein, Dog (Active, 1-327, sf9, GST) is the recombinant dog-derived RIPK1, expressed by Sf9 insect cells , with GST labeled tag. ,

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