Search Result

Results for "

tribbles pseudokinase 1 (TRIB1)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (1) IFNAR (1) IKK (1) Interleukin Related (1) JAK (4) Mixed Lineage Kinase (3) RIP kinase (1) Small Interfering RNA (siRNA) (1) VEGFR (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18710

BMS-066	IKK JAK	Inflammation/Immunology
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC₅₀s of 9 nM and 72 nM, respectively.

HY-141676

HyT36	Others	Others
HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3 ^[1] .

HY-112292

GW806742X 10+ Cited Publications	Mixed Lineage Kinase VEGFR	Others
GW806742X, an ATP mimetic and a potent *MLKL (Mixed Lineage Kinase* Domain-Like protein)** inhibitor, binds the MLKL pseudokinase domain with a K_d of 9.3 μM. GW806742X has activity against VEGFR2 (IC₅₀=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis ^[1] .

HY-112292A

GW806742X hydrochloride 10+ Cited Publications	Mixed Lineage Kinase VEGFR	Cancer
GW806742X hydrochloride, an ATP mimetic and a potent *MLKL (Mixed Lineage Kinase* Domain-Like protein)** inhibitor, binds the MLKL pseudokinase domain with a K_d of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC₅₀=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis ^[1] .

HY-148366

NecroIr2	Mixed Lineage Kinase RIP kinase CDK	Cancer
NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting *serine-threonine kinase* 3 (RIPK3*) and mixed lineage kinase* domain-like pseudokinase (MLKL), and regulates CDK4 expression ^[1].

HY-117287

Deucravacitinib Maximum Cited Publications 16 Publications Verification BMS-986165	JAK Interleukin Related IFNAR	Inflammation/Immunology
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis ^[1] .

HY-156466

QL-1200186	JAK	Inflammation/Immunology
QL-1200186 is anorally activeand selective inhibitor ofTYK2. Oral administration of QL-1200186, dose-dependently inhibitsinterferon-γ(IFNγ) production afterinterleukin-12(IL-12) challenge and significantly ameliorates skin lesions in psoriatic mice ^[1].

HY-RS15015

TRIB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRIB1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRIB1 Human Pre-designed siRNA Set A TRIB1 Human Pre-designed siRNA Set A

HY-123494

BRD0418	Others	Cardiovascular Disease Neurological Disease
BRD0418 is a diversity-oriented synthesis (DOS) molecule that regulates the expression of tribbles pseudokinase 1. BRD0418 has the effect of causing hot lipoprotein metabolism from fat production to clearance. BRD0418 can be used in the study of coronary artery disease (CAD) ^[1].

HY-18709

Tyk2-IN-3	JAK	Inflammation/Immunology
Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC₅₀ of 485 nM.

Species:	Human (4)
Tag:	His (2) GST (4)
Source:	Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P74491

	TRIB3 Protein, Human (sf9, GST) tribbles homolog 3; TRB-3; SINK; C20orf97; NIPK; SKIP3	Human	Sf9 insect cells
	TRIB3 protein is an inactive kinase that centrally regulates the integrated stress response (ISR) and inhibits DDIT3/CHOP transcriptional activity. It causes DDIT3/CHOP-dependent cell death during endoplasmic reticulum (ER) stress, particularly in programmed neuronal cell death. TRIB3 Protein, Human (sf9, GST) is the recombinant human-derived TRIB3 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of TRIB3 Protein, Human (sf9, GST) is 358 a.a., with molecular weight of ~65.8 kDa.

HY-P703032

	TRIB1 Protein, Human (sf9, GST) Pseudouridylate synthase 1 homolog; tRNA pseudouridine synthase 1; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I	Human	Sf9 insect cells
	TRIB1 Protein, Human (sf9, GST) is the recombinant human-derived TRIB1, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P74492

	TRIB2 Protein, Human (sf9, His-GST) tribbles homolog 2; TRB-2; TRIB2; TRB2	Human	Sf9 insect cells
	TRIB2 protein regulates MAP kinase activation by interacting with MAPK kinase, acting as a regulator without intrinsic kinase activity. Emphasizing its role in fine-tuning the MAP kinase signaling pathway. TRIB2 Protein, Human (sf9, His-GST) is the recombinant human-derived TRIB2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag. The total length of TRIB2 Protein, Human (sf9, His-GST) is 343 a.a., with molecular weight of ~66 kDa.

HY-P701725

	VRK3 Protein, Human (Sf9, His, GST) VRK3; Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; Vaccinia-related kinase 3	Human	Sf9 insect cells
	Despite its inactive kinase state, VRK3 protein crucially regulates ERK activity by enhancing the phosphatase activity of DUSP3. The interaction with DUSP3 is pivotal as it dephosphorylates and inactivates ERK in the nucleus. VRK3, also interacting with the small GTPase RAN, forms a network of molecular interactions, positioning it as a key modulator in signaling pathways controlling ERK activity and nuclear cellular processes. VRK3 Protein, Human (Sf9, His, GST) is the recombinant human-derived VRK3 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of VRK3 Protein, Human (Sf9, His, GST) is 473 a.a., .

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-117287

Deucravacitinib 15+ Cited Publications
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis ^[1] .

Deucravacitinib

15+ Cited Publications

Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC₅₀=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. Deucravacitinib inhibits IL-12/23 and type I IFN pathways. Deucravacitinib, the FDA's world first de novo deuterium, is available for study in moderate to severe plaque psoriasis ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82429

	TRIB3 Antibody (YA2174) C20orf97; NIPK; SINK; SKIP3; TRB3; Trib3; tribbles homolog 3; tribbles pseudokinase 3; tribbles3	WB	Human
	TRIB3 Antibody (YA2174) is a biotin-conjugated non-conjugated IgG antibody, targeting TRIB3, with a predicted molecular weight of 40 kDa (observed band size: 40 kDa). TRIB3 Antibody (YA2174) can be used for WB experiment in human background.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

TRIB1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TRIB1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.