TRIB2 Protein, Human (sf9, His-GST)

TRIB2 protein regulates MAP kinase activation by interacting with MAPK kinase, acting as a regulator without intrinsic kinase activity. Emphasizing its role in fine-tuning the MAP kinase signaling pathway. TRIB2 Protein, Human (sf9, His-GST) is the recombinant human-derived TRIB2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag. The total length of TRIB2 Protein, Human (sf9, His-GST) is 343 a.a., with molecular weight of ~66 kDa.

The TRIB2 protein exerts regulatory control over the activation of MAP kinases by interacting with MAPK kinases, despite lacking intrinsic kinase activity itself. This interaction underscores TRIB2's role as a modulator rather than a direct kinase, suggesting its involvement in fine-tuning MAP kinase signaling pathways. Additionally, TRIB2 engages in a specific interaction with COP1, further expanding its potential regulatory influence within cellular processes. The functional implications of these interactions highlight TRIB2 as a key player in orchestrating cellular signaling cascades and warrant further exploration into its intricate regulatory mechanisms.

Human

Sf9 insect cells

C-His;N-GST

Q92519 (M1-N343)

28951  [NCBI]

Approximately 66 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.