2. Epigenetics
  3. Epigenetic Reader Domain
  4. ZEN-3411

ZEN-3411 is a BET inhibitor with IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3411 can be used to form PROTACs to induce degradation of BRD4.

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ZEN-3411 Chemical Structure

ZEN-3411 Chemical Structure

CAS No. : 1952264-36-6

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Description

ZEN-3411 is a BET inhibitor with IC50s of 0.05, 0.05 and 0.06 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3411 can be used to form PROTACs to induce degradation of BRD4[1].

IC50 & Target[1]

BRD4 (BD1)

0.05 μM (IC50)

BRD4 (BD2)

0.05 μM (IC50)

BRD4(BD1BD2)

0.06 μM (IC50)

Molecular Weight

360.41

Formula

C21H20N4O2
CAS No.
SMILES

NC1=CC(C2=C(C)ON=C2C)=CC3=C1N=CN3CC4=CC=C(C5OC5)C=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZEN-3411 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZEN-34111952264-36-6ZEN3411ZEN 3411Epigenetic Reader DomainInhibitorinhibitorinhibit

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