Influenza Virus Inhibitor

Influenza Virus Inhibitors (415):

Cat. No.	Product Name	Effect	Purity

HY-156440

7-51A	Inhibitor
7-51A 是一种有效的 PB2 抑制剂，经 ITC 测定的 K_D 值为 1.64 nM。PB2 是流感 RNA 依赖性 RNA 聚合酶 (RdRP) 的重要亚基。

HY-12751AR

Trimethobenzamide hydrochloride (Standard)	Inhibitor
Trimethobenzamide (hydrochloride) (Standard) is the analytical standard of Trimethobenzamide (hydrochloride). This product is intended for research and analytical applications. Trimethobenzamide hydrochloride is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting.

HY-15230R

Geldanamycin (Standard)	Inhibitor
Geldanamycin (Standard) is the analytical standard of Geldanamycin. This product is intended for research and analytical applications. Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

HY-120690

RO5464466	Inhibitor
RO5464466 is an hemagglutinin (HA) inhibitor of influenza H1N1 viruses. RO5464466 inhibits HA-mediated hemolysis of chicken erythrocytes with the IC₅₀ of 0.29 μM.

HY-14768R

Favipiravir (Standard)	Inhibitor
Favipiravir (Standard) is the analytical standard of Favipiravir. This product is intended for research and analytical applications. Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-111026

PPQ-581	Inhibitor
PPQ-581 is an anti-influenza agent with an EC₅₀ of 1 μM for preventing virus-induced cytopathic effects. PPQ-581 inhibits viral protein synthesis. PPQ-581 blocks the RNP nuclear export and cytoplasmic RNP aggregation.

HY-103160B

EHNA	Inhibitor
EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC₅₀=4 μM) and adenosine deaminase (ADA). EHNA exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC₅₀:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.

HY-159903

TQL-1055	Inhibitor
TQL-1055 is a semi-synthetic analog of the saponin adjuvant QS-21 (HY-101092) and can be used as a prophylactic vaccine adjuvant. TQL-1055 exhibits robust adjuvant activity for influenza antigens. TQL-1055 combined with the acellular pertussis vaccine (aP) shows good tolerance and enhances the antibody response to pertussis toxin (PT) in mice and rabbits. TQL-1055 is promising for research of chronic hepatitis B.

HY-W892911

AV-5080	Inhibitor
AV-5080 is an orally active neuraminidase inhibitor. AV-5080 can be used for the research of influenza A and B viruses.

HY-110093

UNC0638 hydrate	Inhibitor
UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC₅₀ of 15 nM and 19 nM, respectively. UNC0638 hydrate inhibits TNBC cell invasion and migration in vitro. UNC0638 hydrate is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 hydrate has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets.

HY-14904R

Umifenovir (Standard)	Inhibitor
Umifenovir (Standard) is the analytical standard of Umifenovir. This product is intended for research and analytical applications. Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro. Umifenovir shows anti-inflammatory activity.

HY-N2982

Caesalmin E	Inhibitor
Caesalmin E is a natural cassane furanoditerpene with anti-Para3 (Parainfluenza virus type 3) virus activities.

HY-B0402AR

Amantadine hydrochloride (Standard)	Inhibitor
Amantadine (hydrochloride) (Standard) is the analytical standard of Amantadine (hydrochloride). This product is intended for research and analytical applications. Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.

HY-23193

BMS-199945	Inhibitor
BMS-199945 is a influenza virus fusion inhibitor with the IC₅₀ values of 0.57 μM and approximately 1 μM aganist influenza A/WSN/33 virus-induced hemolysis of chicken RBC and in the trypsin protection assay, respectively.

HY-N6715R

Tenuazonic acid (Standard)	Inhibitor
Tenuazonic acid (Standard) is the analytical standard of Tenuazonic acid. This product is intended for research and analytical applications. Tenuazonic acid is a nonhost-selective mycotoxin belonging to the tetramic acids family. Tenuazonic acid inhibits protein biosynthesis on ribosomes by suppressing the release of new protein. Tenuazonic acid is acutely toxic, and oral LD₅₀ is set between 81-186 mg/kg in rats and mice. Tenuazonic acid blocks electron transport beyond the primary quinone receptor (QA) by interacting with the D1 protein and is a *photosystem II (PSII)* inhibitor. In addition, Tenuazonic acid has antiviral effects on measles virus, enterovirus, respiratory virus and so on. Tenuazonic acid has an inhibitory effect on skin cancer.

HY-N6715S

Tenuazonic acid-¹³C₁₀	Inhibitor
Tenuazonic acid-¹³C10 is ¹³C labeled 2,6-Dimethylpyrazine (HY-W040790). 2,6-Dimethylpyrazine is a key aroma compound in Boletus edulis.

HY-P5550

Urumin	Inhibitor
Urumin has antiviral activity against the human influenza A virus. Urumin inhibits the growth of PR8 influenza virus (IC₅₀: 3.8 μM). Urumin targets the conserved stalk of H1 hemagglutini, and is effective at neutralizing drug-resistant H1 influenza viruses. Urumin protects naive mice from lethal influenza infection.

HY-109025AR

Baloxavir (Standard)	Inhibitor
Baloxavir (Standard) is the analytical standard of Baloxavir. This product is intended for research and analytical applications. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity.

HY-135853R

Molnupiravir (Standard)	Inhibitor
Molnupiravir (Standard) is the analytical standard of Molnupiravir. This product is intended for research and analytical applications. Molnupiravir (EIDD-2801) is an orally bioavailable proagent of the ribonucleoside analog EIDD-1931. Molnupiravir has broad spectrum antiviral activity against influenza virus and multiple coronaviruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV. Molnupiravir has the potential for the research of COVID-19, and seasonal and pandemic influenza.

HY-161820

IAV-IN-3	Inhibitor
IAV-IN-3 (Compound (R,S)-16s) is an anti-influenza A virus (IAV) agent (EC₅₀ = 0.134 μM) with weak cytotoxicity (CC₅₀ = 15.35 μM for MDCK cells). IAV-IN-3 inhibits IAV polymerase with an IC₅₀ of 0.045 μM.

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