UNC0638 hydrate

Cat. No.: HY-110093: FAQs
Data Sheet Handling Instructions

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UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferase activity with IC₅₀s of less than 15 nM and 19 nM, respectively. UNC0638 hydrate has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities.

For research use only. We do not sell to patients.

UNC0638 hydrate Chemical Structure

CAS No. : 1255517-77-1

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Other In-stock Forms of UNC0638 hydrate:

UNC0638

Other Forms of UNC0638 hydrate:

UNC0638 In-stock

8 Publications Citing Use of MCE UNC0638 hydrate

: UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]; The effects of treatment with the indicated epigenetic inhibitors on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.

: UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2018 Feb;17(2):2239-2244. [Abstract]; UNC0638 suppresses triple negative breast cancer cell migration and invasion by regulating EMT associated proteins. Western blots of EMT associated proteins.

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•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
Customer Review

Description	UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferase activity with IC₅₀s of less than 15 nM and 19 nM, respectively. UNC0638 hydrate has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities^[1]^[2]^[3].
IC₅₀ & Target	IC50: <15 nM (G9a), 19±1 nM (GLP)^[1]
Molecular Weight	527.74
Formula	C₃₀H₄₉N₅O₃
CAS No.	1255517-77-1
SMILES	CC(N1CCC(NC2=C3C=C(OC)C(OCCCN4CCCC4)=CC3=NC(C5CCCCC5)=N2)CC1)C.O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Vedadi M, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74. [Content Brief] [2]. Fu L, et al. Effects of the Histone Methyltransferase Inhibitor UNC0638 on Histone H3K9 Dimethylation of Cultured Ovine Somatic Cells and Development of Resulting Early Cloned Embryos. Reprod Domest Anim. 2014 Apr;49(2):e21-5. [Content Brief] [3]. Singh N, et al. Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. J Interferon Cytokine Res. 2016 Jan;36(1):37-47. [Content Brief]

UNC0638 hydrate Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC06381255517-77-1UNC 0638UNC-0638VSVHistone MethyltransferaseAutophagyInfluenza VirusVesicular Stomatitis VirusG9aGLP histone methyltransferaseFMDVEZH2,Inhibitorinhibitorinhibit

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