2. Signaling Pathways
  3. Immunology/Inflammation
    Metabolic Enzyme/Protease
    NF-κB
  4. Reactive Oxygen Species

Reactive Oxygen Species

Reactive Oxygen Species

Related Products

PDF 4.04 MB

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2035R
    Moslosooflavone (Standard)
    		Inhibitor
    Moslosooflavone (Standard) is the analytical standard of Moslosooflavone. This product is intended for research and analytical applications. Moslosooflavone is a flavonoid isolated from Andrographis paniculata. Moslosooflavone has an anti-hypoxia and anti-inflammatory activities.
    Moslosooflavone (Standard)
  • HY-N1412R
    1,3-Dicaffeoylquinic acid (Standard)
    1,3-Dicaffeoylquinic acid (Standard) is the analytical standard of 1,3-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 1,3-Dicaffeoylquinic acid is a caffeoylquinic acid derivative that exhibits antioxidant activity and radical scavenging activity.
    1,3-Dicaffeoylquinic acid (Standard)
  • HY-W001187S
    Tempo-d18
    Tempo-d18 is the deuterium labeled Tempo[1]. Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[2][3][4][5].
    Tempo-d<sub>18</sub>
  • HY-N10106
    Dihydromyristicin
    		Inhibitor
    Dihydromyristicin, a plant flavonoid, has potent anti-inflammatory properties. Dihydromyristicin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.
    Dihydromyristicin
  • HY-153873
    MSU38225
    		Inducer
    MSU38225 is an Nrf-2 inhibitor that increases levels of reactive oxygen species (ROS). MSU38225 inhibits the growth of human lung cancer cells and enhances the sensitivity of human lung cancer cells to chemotherapy in vitro and in vivo. MSU38225 can be used in cancer research.
    MSU38225
  • HY-151940
    Mal-Pc
    		Activator
    Mal-Pc is a versatile molecular photosensitizer designed based phthalocyanine and maleimides. Mal-Pc can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS (Reactive Oxygen Species)-mediated effect of photodynamic therapy (PDT) in cancer cells.
    Mal-Pc
  • HY-146058
    NF-κB/PON1-IN-1
    		Inhibitor
    NF-κB/PON1-IN-1 (Compound 16) is a NF-κB/PON1 pathway inhibitor. NF-κB/PON1-IN-1 has antioxidant (IC50 = 45.76 µM) and hepatoprotective activities.
    NF-κB/PON1-IN-1
  • HY-114716
    Jacareubin
    		Inhibitor
    Jacareubin is a xanthone compound that can be isolated from Calophyllum brasiliense. Jacareubin has antibacterial, antioxidant, gastroprotective properties, and also has certain cancer cell toxicity, which can be used in cancer research.
    Jacareubin
  • HY-B0987R
    Ascorbyl palmitate (Standard)
    Ascorbyl palmitate (Standard) is the analytical standard of Ascorbyl palmitate. This product is intended for research and analytical applications. Ascorbyl palmitate is an ester formed from ascorbic acid and palmitic acid creating an vitamin C, it is also used as an antioxidant food additive.
    Ascorbyl palmitate (Standard)
  • HY-B0356AR
    Ciprofloxacin monohydrochloride (Standard)
    		Inducer
    Ciprofloxacin (monohydrochloride) (Standard) is the analytical standard of Ciprofloxacin (monohydrochloride). This product is intended for research and analytical applications. Ciprofloxacin (Bay-09867) monohydrochloride is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin monohydrochloride induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin monohydrochloride has anti-proliferative activity and induces apoptosis. Ciprofloxacin monohydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[4].
    Ciprofloxacin monohydrochloride (Standard)
  • HY-N0052C
    Sanguinarine (gluconate)
    		Agonist
    Sanguinarine (Sanguinarin) gluconate, a benzophenanthridine alkaloid, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
    Sanguinarine (gluconate)
  • HY-168097
    Ferroptosis inducer-6
    		Inducer
    Ferroptosis inducer 6 (6d) is a ferroptosis inducer with high potency for type I/-II photodynamic therapy by inducing ROS generation, oxidative stress and mitochondrial damage. Ferroptosis inducer 6 has anti-tumor activity.
    Ferroptosis inducer-6
  • HY-130237R
    Cinnamtannin B-1 (Standard)
    		Inhibitor
    Cinnamtannin B-1 (Standard) is the analytical standard of Cinnamtannin B-1. This product is intended for research and analytical applications. Cinnamtannin B-1 is a proanthocyanidin with multiple biological functions, including antioxidant effects and inhibiting the production of reactive oxygen species (ROS). Cinnamtannin B-1 inhibits RANKL-induced osteoclastogenesis and prevents ovariectomy-induced osteoporosis in vivo. Cinnamtannin B-1 can be used for the research osteoporosis and colon cancers.
    Cinnamtannin B-1 (Standard)
  • HY-155568
    Anti-inflammatory agent 47
    Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO) and suppresses neuronal apoptotic by inhibiting inflammatory and apoptotic signaling pathways. Flo8 can be used for Parkinson's Disease (PD) research.
    Anti-inflammatory agent 47
  • HY-N0523R
    Gallic acid (Standard)
    Gallic acid (Standard) is the analytical standard of Gallic acid. This product is intended for research and analytical applications. Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2). Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities.
    Gallic acid (Standard)
  • HY-N8054
    1-Hydroxypinoresinol 1-O-β-D-glucoside
    		Inhibitor
    1-Hydroxypinoresinol 1-O-β-D-glucoside (Compound 4) is an antioxidative compound.
    1-Hydroxypinoresinol 1-O-β-D-glucoside
  • HY-W015913S4
    2-Oxopropanoate-13C5 sodium
    2-Oxopropanoate-13C5 (sodium) is the 13C labeled Sodium 2-oxopropanoate[1]. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[2][3].
    2-Oxopropanoate-<sup>13</sup>C<sub>5</sub> sodium
  • HY-12590
    Glutathione oxidized disodium
    Glutathione oxidized disodium is produced by the oxidation of glutathione which is a major intracellular antioxidant and detoxifying agent.
    Glutathione oxidized disodium
  • HY-N10593
    Ladanetin-6-O-β-D-glucopyranoside
    		Inhibitor
    Ladanetin-6-O-β-D-glucopyranoside is an active flavonoid. Ladanetin-6-O-β-D-glucopyranoside has antioxidative effect. Ladanetin-6-O-β-D-glucopyranoside can be used for the research of cardioprotective effects.
    Ladanetin-6-O-β-D-glucopyranoside
  • HY-161850
    ULK1-IN-3
    		Agonist
    ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines.
    ULK1-IN-3
Cat. No. Product Name / Synonyms Application Reactivity