Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (575)
Antibodies (4)
Topoisomerase Isoform Comparison

By Effects:	Controls (3) Inhibitors (550) Agonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15142

Doxorubicin hydrochloride	Inhibitor	99.90%
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.

HY-13629

Etoposide	Inhibitor	99.94%
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.

HY-13631A

Exatecan mesylate	Inhibitor	99.97%
Exatecan mesylate (DX8951f) is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research.

HY-13631D

Dxd	Inhibitor	99.43%
Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC₅₀ of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).

HY-13704

SN-38	Inhibitor	99.89%
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).

HY-13631AS

Exatecan-d₅ mesylate	Inhibitor	99.82%
c is deuterium labeled Exatecan mesylate (HY-13631A). Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL). Exatecan mesylate can be used in cancer research.

HY-164792

DBCO-PEG3-VC-Exatecan	Inhibitor
DBCO-PEG3-VC-Exatecan (compound 25) is a Drug-Linker Conjugate for ADC. DBCO-PEG3-VC-Exatecan contains the ADC linker (DBCO-PEG3-VC) and a DNA topoisomerase I inhibitor Exatecan (HY-13631).

HY-159783

Mal-Exatecan	Inhibitor
Mal-Exatecan is a Mal (Maleimide) modified Exatecan (HY-13631), a DNA topoisomerase I (topoisomerase I) inhibitor.

HY-16560

Camptothecin	Inhibitor	99.86%
Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.

HY-16562

Irinotecan	Inhibitor	99.97%
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.

HY-13631

Exatecan	Inhibitor	99.93%
Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC₅₀ of 2.2 μM (0.975 μg/mL), and can be used in cancer research.

HY-13768A

Topotecan hydrochloride	Inhibitor	99.89%
Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.

HY-13062

Daunorubicin hydrochloride	Inhibitor	99.67%
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.

HY-13502

Mitoxantrone	Inhibitor	99.58%
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity. Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively.

HY-18258

Berberine chloride	Inhibitor	99.92%
Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.

HY-13624A

Epirubicin hydrochloride	Inhibitor	99.16%
Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.

HY-16562A

Irinotecan hydrochloride	Inhibitor	99.89%
Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.

HY-141598

Datopotamab deruxtecan	Inhibitor	99.54%
Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity.

HY-42487

Exatecan Intermediate 1	Inhibitor	99.99%
Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects.

HY-B0330

Levofloxacin	Inhibitor	99.92%
Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity.

Doxorubicin hydrochloride		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM	99.90%
Etoposide			Topoisomerase II	99.94%
Dxd		Topoisomerase I, IC₅₀: 0.31 μM		99.43%
SN-38		Topoisomerase I		99.89%
Camptothecin		Topoisomerase I, IC₅₀: 679 nM		99.86%
Irinotecan		Topoisomerase I		99.97%
Topotecan hydrochloride		Topoisomerase I		99.89%
Daunorubicin hydrochloride			Topoisomerase II	99.67%
Mitoxantrone			Topoisomerase II	99.58%
Epirubicin hydrochloride	Topoisomerase			99.16%
Irinotecan hydrochloride		Topoisomerase I		99.89%
Datopotamab deruxtecan		Topoisomerase I		99.54%
Levofloxacin	TOPO IV			99.92%
Idarubicin hydrochloride			Topoisomerase II	99.94%
Betulinic acid		Topoisomerase I, IC₅₀: 5 μM		99.06%
Mitoxantrone dihydrochloride			Topoisomerase II	99.55%
β-Lapachone		Topoisomerase I		99.96%
Dxd-d₅		Topoisomerase I, IC₅₀: 0.31 μM		98.84%
Teniposide			Topoisomerase II	99.00%
Pirarubicin			Topoisomerase II	99.61%
Irinotecan hydrochloride trihydrate		Topoisomerase I		99.89%
Belotecan hydrochloride		Top1		99.88%
Etoposide phosphate			Topoisomerase II
PNU-159682		Topoisomerase I		98.25%
Aclacinomycin A		Topoisomerase I	Topoisomerase II	99.30%
Aldoxorubicin			Topoisomerase II
Aurintricarboxylic acid			Topoisomerase II
Banoxantrone dihydrochloride			Topoisomerase II	99.46%
Nalidixic acid	Topoisomerase			99.97%
Proscillaridin A		Topoisomerase I, IC₅₀: 30 nM	Topoisomerase II, IC₅₀: 100 nM	99.74%
Levofloxacin hydrate	TOPO IV			99.93%
Pirarubicin Hydrochloride			Topoisomerase II	99.14%
Pixantrone			Topoisomerase II	98.75%
(S)-10-Hydroxycamptothecin		Topoisomerase I		99.38%
Ellipticine			Topoisomerase II	99.56%
Bisantrene			Topoisomerase II	98.08%
Amsacrine			Topoisomerase II	99.95%
Gatifloxacin			Topoisomerase II, IC₅₀: 36.7 μM	99.69%
MC-GGFG-AM-(10Me-11F-Camptothecin)		Topoisomerase I		98.06%
Ellipticine hydrochloride			Topoisomerase II	99.34%
PluriSIn #2			topoisomerase II alpha	≥98.0%
Hycanthone		Topoisomerase I	Topoisomerase II	99.97%
Amonafide			Topoisomerase II	99.92%
Voreloxin Hydrochloride			Topoisomerase II	99.58%
Coralyne chloride		Topoisomerase I		98.30%
Amsacrine hydrochloride			Topoisomerase II	99.98%
Amrubicin			Topoisomerase II	≥98.0%
9-Aminocamptothecin		Topoisomerase I		98.89%
TAS-103 dihydrochloride		Topoisomerase I	Topoisomerase II	98.87%
Genz-644282		Topoisomerase I		99.53%
MC-DOXHZN hydrochloride			Topoisomerase II	98.04%
Chloroquinoxaline sulfonamide			topoisomerase II alpha topoisomerase II beta	99.06%
Indotecan		Topoisomerase I		≥98.0%
(±)-10-Hydroxycamptothecin		Topoisomerase I		99.57%
Nalidixic acid sodium salt	Topoisomerase			99.83%
Flumequine			Topoisomerase II, IC₅₀: 15 μM
Daun02	Topoisomerase			98.72%
Intoplicine		Topoisomerase I	Topoisomerase II	98.36%
Gimatecan		Topoisomerase I		99.28%
Gatifloxacin hydrochloride			Topoisomerase II, : 36.7 μM	99.94%
Lurtotecan		Topoisomerase I		98.01%
Isodiospyrin		Topoisomerase I		99.77%
(±)-Evodiamine		Top1		99.74%
Karenitecin		Topoisomerase I		98.02%
LMP744 hydrochloride		Top1		99.70%
Levofloxacin hydrochloride	TOPO IV			≥98.0%
Groenlandicine		Topoisomerase I		99.87%
Indimitecan		Top1		98.30%
Namitecan		Topoisomerase I		99.25%
ARN-21934			topoisomerase II alpha topoisomerase II beta	98.08%
Podocarpusflavone A		Topoisomerase I, IC₅₀: 119.425 μM		99.62%
LMP517		Topoisomerase I	Topoisomerase II	99.58%
Garenoxacin Mesylate hydrate	TOPO IV, IC₅₀: 1.5-2.5 μg/mL			99.78%
LMP744		Top1		98.85%
Aclacinomycin A hydrochloride		Topoisomerase I	Topoisomerase II
Topoisomerase I inhibitor 8		Topoisomerase I
Elomotecan hydrochloride		Topoisomerase I	Topoisomerase II
Epirubicin	Topoisomerase			98.45%
Topoisomerase II inhibitor 20 TFA			Topoisomerase II, IC₅₀: 0.98 μM
Zabofloxacin hydrochloride		Topoisomerase I	Topoisomerase II	99.54%
9-Hydroxyellipticine hydrochloride			Topoisomerase II	≥99.0%
SW044248		Topoisomerase I		99.60%
Topotecan		Topoisomerase I
Doxorubicin		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM
Daunorubicin			Topoisomerase II
Topoisomerase II inhibitor 20			Topoisomerase II, IC₅₀: 0.98 μM	98.44%
CH-0793076		Topoisomerase I, IC₅₀: 2.3 μM
AQ4			Topoisomerase II
BNS-22			topoisomerase II alpha, IC₅₀: 2.8 μM (in human) topoisomerase II beta, IC₅₀: 0.42 μM (in human)	99%
Seconeolitsine		Topoisomerase I, IC₅₀: 17 μM
Edotecarin		Topoisomerase I, IC₅₀: 50 nM		98.39%
CH-0793076 TFA		Topoisomerase I, IC₅₀: 2.3 μM		98.71%
Zabofloxacin		Topoisomerase I	Topoisomerase II	98.02%
Amrubicin hydrochloride			Topoisomerase II
Pixantrone free base			Topoisomerase II
Voreloxin			Topoisomerase II	99.26%
TAS-103		Topoisomerase I	Topoisomerase II
MC-DOXHZN			Topoisomerase II
Topotecan hydrochloride hydrate		Topoisomerase I
Etoposide phosphate disodium			Topoisomerase II
Idarubicin			Topoisomerase II
Gatifloxacin sesquihydrate			Topoisomerase II, IC₅₀: 36.7 μM
Rebeccamycin		Topoisomerase I
Mitoxantrone diacetate			Topoisomerase II
CBX-12		Topoisomerase I
Daunorubicin citrate			Topoisomerase II
Antitumor agent-63		Top1
Silatecan		Topoisomerase I
Topoisomerase II inhibitor 9			Topoisomerase II, IC₅₀: 0.97 μM
Topo I/COX-2-IN-1		Topoisomerase I, IC₅₀: 4.42 μM
Bimolane			Topoisomerase II
T-2513 hydrochloride		Topoisomerase I
TOPOI/PARP-1-IN-2		Top1, IC₅₀: 46.2 nM
Topo I/COX-2-IN-2		Topoisomerase I, IC₅₀: 0.90 μM
Topoisomerase II inhibitor 11			Topoisomerase II, IC₅₀: 2.89 μM
CS1			topoisomerase II alpha
T-2513		Topoisomerase I
Razoxane			Topoisomerase II	99.16%
Topoisomerase IIα-IN-3			topoisomerase II alpha
Heliquinomycin		Topoisomerase I	Topoisomerase II
Topoisomerase II/EGFR-IN-1			Topoisomerase II
VcMMAE-Deruxtecan		Topoisomerase I
Anticancer agent 75			Topoisomerase II
CP-67804			Topoisomerase II
DTS-108		Top1
Pixantrone hydrochloride			Topoisomerase II
Topoisomerase II inhibitor 4			Topoisomerase II
Topoisomerase IIα-IN-6			topoisomerase II alpha, IC₅₀: 0.67 μM
Topoisomerase IIα-IN-2			topoisomerase II alpha topoisomerase II beta
Topoisomerase IIα-IN-4			topoisomerase II alpha, IC₅₀: 3.8 μM topoisomerase II beta, IC₅₀: 10.1 μM
ZLHQ-5f		Top1
3-Fluoro-evodiamine glucose		Topoisomerase I	Topoisomerase II
Topo I-IN-1		Topoisomerase I
Topoisomerase I/II inhibitor 6		Topoisomerase I, IC₅₀: 4.77 μM	Topoisomerase II, IC₅₀: 15 μM
EGFR-IN-116			Topoisomerase II, IC₅₀: 19.74 μM
Top/HDAC-IN-2		Top1	Topoisomerase II
Anti-MRSA agent 7	TOPO IV, IC₅₀: 0.059 μM (E. coli ) TOPO IV, IC₅₀: 0.341 μM (S. aureus)
Topoisomerase II inhibitor 18			Topoisomerase II, IC₅₀: 7.5 μM
Topoisomerase I inhibitor 17		Top1
Elomotecan		Topoisomerase I	Topoisomerase II
Topoisomerase II inhibitor 5			Topoisomerase II
LE01		Topoisomerase I
HSP90-IN-13	Topoisomerase-2, IC₅₀: 25.85 nM
Topoisomerase I inhibitor 2		Topoisomerase I, IC₅₀: 0.58 μM
iNOS/TopoI-IN-1		Topoisomerase I, Ki: 2.72 μM
Topoisomerase II inhibitor 10			Topoisomerase II, IC₅₀: 7.45 μM
Salvicine			Topoisomerase II, IC₅₀: 3 μM
Topoisomerase IV inhibitor 1	TOPO IV, IC₅₀: 0.23 μM
Topoisomerase II inhibitor 13			Topoisomerase II	99.26%
EGFR-IN-57			topoisomerase II beta, IC₅₀: 0.13 μM
Topoisomerase IIα-IN-1			topoisomerase II alpha topoisomerase II beta
Huanglongmycin N		Topoisomerase I, EC₅₀: 14 μM
Topoisomerase IIα-IN-8			topoisomerase II alpha
Tilatamig samrotecan		Topoisomerase I
Deruxtecan-Eribulin		Topoisomerase I
CP-67015			Topoisomerase II
Tapcin		Topoisomerase I, IC₅₀: 203 nM	Topoisomerase II, IC₅₀: 71 nM
Topoisomerase I inhibitor 12		Topoisomerase I
Topoisomerase II inhibitor 17			Topoisomerase II, IC₅₀: 0.23 μM
Topoisomerase I/II inhibitor 2		Topoisomerase I	Topoisomerase II
Topo I/II-IN-2		Topoisomerase I	Topoisomerase II
Saintopin		Topoisomerase I	Topoisomerase II
Intoplicine dimesylate		Topoisomerase I	Topoisomerase II	98.28%
Topoisomerase IV inhibitor 2	TOPO IV, IC₅₀: 0.35 μM
Topoisomerase II inhibitor 7			topoisomerase II alpha, IC₅₀: 3.19 μM
Topoisomerase I/II inhibitor 7		Topoisomerase I	Topoisomerase II
Topoisomerase IIα-IN-7			topoisomerase II alpha, IC₅₀: 7.7 μM
Niranthin	Topoisomerase
Epolactaene			Topoisomerase II, IC₅₀: 10 μM
Topoisomerase I inhibitor 3		Topoisomerase I
Topoisomerase II inhibitor 19			Topoisomerase II, IC₅₀: 0.34 μM
Corydamine		Topoisomerase I	Topoisomerase II
TP0480066			Topoisomerase II
AZD5099			Topoisomerase II
Topoisomerase I inhibitor 16		Topoisomerase I
TP3011		Topoisomerase I
Topoisomerase II inhibitor 8			Topoisomerase II, IC₅₀: 0.52 μM
Topoisomerase I/II inhibitor 3		Topoisomerase I	Topoisomerase II
Gatifloxacin mesylate			Topoisomerase II, IC₅₀: 36.7 μM
Topoisomerase IIα-IN-5			topoisomerase II alpha
Bakuchicin			Topoisomerase II, IC₅₀: 404 μM
Thaspine acetate		Topoisomerase I	Topoisomerase II
Antibacterial agent 229	TOPO IV, IC₅₀: 10.88 μM
(-)-BO 2367			Topoisomerase II
8-Chloro-ATP tetrasodium			Topoisomerase II
Garenoxacin	TOPO IV, IC₅₀: 1.5-2.5 μg/mL
HU 331			Topoisomerase II
Luotonin F			Topoisomerase II
Topovale		Topoisomerase I
NK 314			topoisomerase II alpha
8-Chloro-ATP			Topoisomerase II

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Topoisomerase

Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (575)

Antibodies (4)

Topoisomerase Isoform Comparison

Topoisomerase Related Products (575):