2. Autophagy Apoptosis Epigenetics Cell Cycle/DNA Damage NF-κB PI3K/Akt/mTOR Immunology/Inflammation Metabolic Enzyme/Protease
  3. ULK Apoptosis PARP Autophagy NF-κB AMPK Akt Reactive Oxygen Species
  4. ULK1-IN-3

ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines.

For research use only. We do not sell to patients.

ULK1-IN-3 Chemical Structure

ULK1-IN-3 Chemical Structure

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ULK1-IN-3 Related Antibodies

Top Publications Citing Use of Products

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ULK1 ULK2

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Akt Akt1 Akt2 Akt3

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Description

ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines[1].

IC50 & Target

ULK1

 

In Vitro

ULK1-IN-3 (0-20 μM, 72 h) shows an effective growth inhibitor against 786-O, MCF-7, SW620 and T-24 colon cancer cell lines, most effective against SW620 cells with a LC50 value of 3.2 μM, slightly surpassing 5-Fluorouracil (HY-90006)[1].
ULK1-IN-3 (1.25-10 μM, 24 h) induces G2/M and S phase cell arrest in SW620 cells[1].
ULK1-IN-3 (1.25-5 μM, 48 h) triggers the intrinsic apoptotic pathway, potentially by elevating the production of ROS in SW620 cells. Additionally, ULK1-IN-3 up-regulates cleaved PARP (cPARP) and the expression of NFκβ and AMPK, but down-regulates the expression of the AKT in SW620 cells[1].

LC50 values of ULK1-IN-3 for the inhibition of cancer cell viability[1]

Compounds 786-O MCF-7 SW620 T-24
ULK1-IN-3 4.5±0.15 4.3±1.90 3.2±0.10 3.5±0.42

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ULK1-IN-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: 786-O, MCF-7, SW620 and T-24 colorectal cancer cells
Concentration: 0-20 μM
Incubation Time: 72 h
Result: Inhibited the viability of 786-O, MCF-7, SW620 and T-24 cancer cells by more than 80% at 20 μM.

Cell Cycle Analysis[1]

Cell Line: SW620 cells
Concentration: 1.25-10 μM
Incubation Time: 24 h
Result: Induced G2/M and S phase cell arrest and decreased the proportion of cells in the G0/G1 phase in SW620 cells.

Western Blot Analysis[1]

Cell Line: SW620 cells
Concentration: 1.25-5 μM
Incubation Time: 48 h
Result: Up-regulated cleaved PARP (cPARP) and the expression of NFκβ and AMPK, enhanced the availability of pro-apoptotic BCL-2 agonist of cell death (BAD) and multidomain effector protein BCL-2 antagonist/killer (BAK), increased autophagy marker light chain 3B (LC3B) lipidation, but down-regulated the expression of the AKT in SW620 cells.
Molecular Weight

436.88

Formula

C25H21ClO5
SMILES

COC1=CC=C(C(C(C2=CC=C(CCl)C=C2)=C(C3=CC=C(OC)C(OC)=C3)O4)=O)C4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ULK1-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ULK1-IN-3ULKApoptosisPARPAutophagyNF-κBAMPKAktReactive Oxygen SpeciesUnc-51 like kinasepoly ADP ribose polymerase Nuclear factor-κBNuclear factor-kappaBAMP-activated protein kinasePKBProtein kinase BchromoneULK1growth inhibitorcell cycleautophagyapoptosiscolorectal cancer cellscolon cancerInhibitorinhibitorinhibit

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