2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. Antibody-Drug Conjugates (ADCs) CD22
  4. Anti-CD22-NMS249

Anti-CD22-NMS249 is a CD22-targeting antibody-drug conjugate (ADC). Anti-CD22-NMS249 is composed of a humanized anti-CD22 antibody Pinatuzumab (HY-P99230), a cleavable linker (Mc-VC-PAB), and a DNA topoisomerase II inhibitor payload PNU-159682 (HY-16700). Anti-CD22-NMS249 can be used for research in non-Hodgkin lymphoma (NHL).

For research use only. We do not sell to patients.

Anti-CD22-NMS249 Chemical Structure

Anti-CD22-NMS249 Chemical Structure

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Anti-CD22-NMS249 Related Antibodies

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Description

Anti-CD22-NMS249 is a CD22-targeting antibody-drug conjugate (ADC). Anti-CD22-NMS249 is composed of a humanized anti-CD22 antibody Pinatuzumab (HY-P99230), a cleavable linker (Mc-VC-PAB), and a DNA topoisomerase II inhibitor payload PNU-159682 (HY-16700). Anti-CD22-NMS249 can be used for research in non-Hodgkin lymphoma (NHL)[1].

In Vitro

Anti-CD22-NMS249 inhibits the proliferation of NHL cell lines with IC50 values ​​of 0.058 μg/mL, 0.030 μg/mL, 0.0221 μg/mL and 0.010 μg/mL for BJAB.Luc, Granta-519, SuDHL4.Luc and WSU-DLCL2 cells， respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-CD22-NMS249 Related Antibodies
In Vivo

Anti-CD22-NMS249 (0.5-2 mg/kg; IV; a single dose) results in tumor stasis in four xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CB17 ICR SCID mice injected with BJAB.Luc, Granta-519, SuDHL4.Lu or WSU-DLCL2 cells[1]
Dosage: 0.5, 1, or 2 mg/kg
Administration: IV; a single dose
Result: Was active in all four models.
SMILES

[Anti-CD22-NMS249]
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Purity & Documentation
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Anti-CD22-NMS249 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-CD22-NMS249Antibody-Drug Conjugates (ADCs)CD22Antibody-Drug ConjugatesSiglec 2CD22 ADCnon-Hodgkin lymphomaPinatuzumabMc-VC-PABPNU-159682Inhibitorinhibitorinhibit

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