Benzovindiflupyr

Name: Benzovindiflupyr
Brand: MedChemExpress
SKU: HY-W587754
Rating: 4.5 (1 reviews)

Cat. No.: HY-W587754 Purity: 99.56%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Benzovindiflupyr is a succinate dehydrogenase inhibitor (SDHI). Benzovindiflupyr has high activity against S. sclerotiorum. Benzovindiflupyr can be used for the research of sclerotinia stem rot.

For research use only. We do not sell to patients.

Benzovindiflupyr Chemical Structure

CAS No. : 1072957-71-1

Size	Price	Stock	Quantity
5 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Benzovindiflupyr:

Benzovindiflupyr (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Benzovindiflupyr is a succinate dehydrogenase inhibitor (SDHI). Benzovindiflupyr has high activity against S. sclerotiorum. Benzovindiflupyr can be used for the research of sclerotinia stem rot^[1].

Molecular Weight

398.23

Formula

C₁₈H₁₅Cl₂F₂N₃O

CAS No.

1072957-71-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC3=C2C4CCC3/C4=C(Cl)/Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (251.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5111 mL	12.5556 mL	25.1111 mL
5 mM	0.5022 mL	2.5111 mL	5.0222 mL
10 mM	0.2511 mL	1.2556 mL	2.5111 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.56%

Select Batch:

Data Sheet (275 KB) SDS (624 KB)

COA (254 KB) RP-HPLC (129 KB)

Handling Instructions (2659 KB)

References

[1]. Gao Y, et al. The relationship between features enabling SDHI fungicide binding to the Sc-Sdh complex and its inhibitory activity against Sclerotinia sclerotiorum. Pest Manag Sci. 2020 Aug;76(8):2799-2808. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5111 mL	12.5556 mL	25.1111 mL	62.7778 mL
	5 mM	0.5022 mL	2.5111 mL	5.0222 mL	12.5556 mL
	10 mM	0.2511 mL	1.2556 mL	2.5111 mL	6.2778 mL
	15 mM	0.1674 mL	0.8370 mL	1.6741 mL	4.1852 mL
	20 mM	0.1256 mL	0.6278 mL	1.2556 mL	3.1389 mL
	25 mM	0.1004 mL	0.5022 mL	1.0044 mL	2.5111 mL
	30 mM	0.0837 mL	0.4185 mL	0.8370 mL	2.0926 mL
	40 mM	0.0628 mL	0.3139 mL	0.6278 mL	1.5694 mL
	50 mM	0.0502 mL	0.2511 mL	0.5022 mL	1.2556 mL
	60 mM	0.0419 mL	0.2093 mL	0.4185 mL	1.0463 mL
	80 mM	0.0314 mL	0.1569 mL	0.3139 mL	0.7847 mL
	100 mM	0.0251 mL	0.1256 mL	0.2511 mL	0.6278 mL