2. Anti-infection Neuronal Signaling
  3. Bacterial Cholinesterase (ChE)
  4. Dimethyl sulfoxide

Dimethyl sulfoxide  (Synonyms: DMSO)

Cat. No.: HY-Y0320 Purity: 99.98%
SDS COA Handling Instructions

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Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties.
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).

For research use only. We do not sell to patients.

Dimethyl sulfoxide Chemical Structure

Dimethyl sulfoxide Chemical Structure

CAS No. : 67-68-5

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Based on 139 publication(s) in Google Scholar

Other Forms of Dimethyl sulfoxide:

Dimethyl sulfoxide Related Antibodies

Top Publications Citing Use of Products

139 Publications Citing Use of MCE Dimethyl sulfoxide

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Description

Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves polar and non-polar compounds, including water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity. Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties[1][2][3].
MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch.P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition).

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
232 μM
Compound: DMSO
Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
Antiproliferative activity against HEK293 cells after 48 hrs by MTT assay
[PMID: 27108400]
HL-60 IC50
108 μM
Compound: DMSO
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 27108400]
LN-18 IC50
223 μM
Compound: DMSO
Antiproliferative activity against human LN18 cells after 48 hrs by MTT assay
Antiproliferative activity against human LN18 cells after 48 hrs by MTT assay
[PMID: 27108400]
MDCK-II GI50
123 μM
Compound: DMSO
Growth inhibition of MDCK2 cells after 72 hrs by MTT assay
Growth inhibition of MDCK2 cells after 72 hrs by MTT assay
[PMID: 32787102]
MDCK-II GI50
137 μM
Compound: DMSO
Growth inhibition of MDCK2 cells over expressing human ABCG2 after 72 hrs by MTT assay
Growth inhibition of MDCK2 cells over expressing human ABCG2 after 72 hrs by MTT assay
[PMID: 32787102]
THP-1 IC50
119 μM
Compound: DMSO
Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay
Antiproliferative activity against human THP1 cells after 48 hrs by MTT assay
[PMID: 27108400]
In Vitro

DMSO is an organic solvent that is freely miscible with water, lipids and organic agents. These properties allow for exceptional membrane penetration. The mechanism of action of DMSO is thought to be a combination of anti-inflammatory effects, nerve blockade, smooth muscle relaxation, and collagen inhibition[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethyl sulfoxide Related Antibodies
Clinical Trial
Molecular Weight

78.13

Formula

C2H6OS
CAS No.
Appearance

<18.4°C Solid,>18.4°C Liquid

Color

Colorless to off-white

SMILES

O=S(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (2559.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 12.7992 mL 63.9959 mL 127.9918 mL
5 mM 2.5598 mL 12.7992 mL 25.5984 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 100.0%

SDS (393 KB)

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 12.7992 mL 63.9959 mL 127.9918 mL 319.9795 mL
5 mM 2.5598 mL 12.7992 mL 25.5984 mL 63.9959 mL
10 mM 1.2799 mL 6.3996 mL 12.7992 mL 31.9980 mL
15 mM 0.8533 mL 4.2664 mL 8.5328 mL 21.3320 mL
20 mM 0.6400 mL 3.1998 mL 6.3996 mL 15.9990 mL
25 mM 0.5120 mL 2.5598 mL 5.1197 mL 12.7992 mL
30 mM 0.4266 mL 2.1332 mL 4.2664 mL 10.6660 mL
40 mM 0.3200 mL 1.5999 mL 3.1998 mL 7.9995 mL
50 mM 0.2560 mL 1.2799 mL 2.5598 mL 6.3996 mL
60 mM 0.2133 mL 1.0666 mL 2.1332 mL 5.3330 mL
80 mM 0.1600 mL 0.7999 mL 1.5999 mL 3.9997 mL
100 mM 0.1280 mL 0.6400 mL 1.2799 mL 3.1998 mL
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Dimethyl sulfoxide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethyl sulfoxide67-68-5DMSOBacterialCholinesterase (ChE)anti-freezingbacteriostaticanti-inflammatoryaproticsolventInhibitorinhibitorinhibit

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