UPP2 - uridine phosphorylase 2 Gene

Homo sapiens

Also known as UP2; UPASE2; UDRPASE2

Gene ID: 151531 | Gene type: protein coding

About UPP2

Cytogenetic location: 2q24.1 Genomic coordinates (GRCh38): 2:157,995,179-158,136,154 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Restricted expression toward kidney (RPKM 10.8).

Summary

Enables deoxyuridine phosphorylase activity; identical protein binding activity; and uridine phosphorylase activity. Involved in dCMP catabolic process and uridine catabolic process. Located in type III intermediate filament. [provided by Alliance of Genome Resources, Apr 2022]

UPP2 Products(2)

mRNA	Protein	Name
NM_001135098.2	NP_001128570.1	uridine phosphorylase 2 isoform b
NM_173355.4	NP_775491.1	uridine phosphorylase 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables deoxyuridine phosphorylase activity	IDA IDA: Inferred from direct assay	12849978	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21855639	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables uridine phosphorylase activity	IDA IDA: Inferred from direct assay	12849978	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in dCMP catabolic process	IDA IDA: Inferred from direct assay	12849978	GOA
involved in uridine catabolic process	IDA IDA: Inferred from direct assay	12849978	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in type III intermediate filament	IDA IDA: Inferred from direct assay	11278417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPP2 Protein Structure

PNP_UDP_1

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

uridine phosphorylase 2

UPase 2

UPP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UPP2	O95045	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	UPP2	O95045	UPP2	Homo sapiens	O95045	Y2H Array	29892012
Intra	UPP2	O95045	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	UPP2	O95045	UPP2	Homo sapiens	O95045	Y2H Array	31515488
Intra	UPP2	O95045	CCZ1B	Homo sapiens	P86790	Anti Tag CoIP	33961781
Intra	UPP2	O95045	UPP2	Homo sapiens	O95045	Y2H Array	25416956
Intra	UPP2	O95045	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myopathy, Myosin Storage, Autosomal Dominant

MSMA	Myopathy, Hyaline Body, Autosomal Dominant
Myopathy With Lysis Of Type I Myofibrils	Autosomal Dominant Hyaline Body Myopathy
Hyaline Body Myopathy Autosomal Dominant

Terminal Osseous Dysplasia

Terminal Osseous Dysplasia And Pigmentary Defects	Terminal Osseous Dysplasia-Pigmentary Defects Syndrome
Todpd	TOD
Odpd	Odpf Syndrome
Osseous Dysplasia, Digital, With Facial Pigmentary Defects And Multiple Frenula	Odpf
Digital Osseous Dysplasia With Facial Pigmentary Defects And Multiple Frenula	Terminal Osseous Dysplasia With Pigmentary Defects
Dcd	Digitocutaneous Dysplasia
Terminal Osseous Dysplasia And Pigmentary Defect Syndrome	Osseous Dysplasia And Pigmentary Defects

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15491	UPP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UPP2	VGNC	VGNC:79372
Rattus norvegicus	UPP2	RGD	RGD:1308188
Bos taurus	UPP2	VGNC	VGNC:36689
Mus musculus	UPP2	MGD	MGI:1923904

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