2. Gene
  3. Tnni3 - troponin I, cardiac 3 Gene

Tnni3 - troponin I, cardiac 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tn1; cTnI

Gene ID: 21954 | Gene type: protein coding

About Tnni3

Summary

Predicted to enable several functions, including Calcium Channel Inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Acts upstream of or within several processes, including cellular calcium ion homeostasis; circulatory system development; and regulation of systemic arterial blood pressure by ischemic conditions. Located in sarcomere. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and sensory organ. Used to study hypertrophic cardiomyopathy 7 and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNI3 (troponin I3, cardiac type). [provided by Alliance of Genome Resources, Apr 2022]

Tnni3 Products(1)

mRNA Protein Name
NM_009406.4 NP_033432.1 troponin I, cardiac muscle
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within heart development IDA
IDA: Inferred from direct assay
15611140 MGI
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
11356618 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
11158984 MGI
acts upstream of or within regulation of muscle contraction IDA
IDA: Inferred from direct assay
12551921 MGI
acts upstream of or within regulation of systemic arterial blood pressure by ischemic conditions IMP
IMP: Inferred from mutant phenotype
11158984 MGI
acts upstream of or within striated muscle contraction IDA
IDA: Inferred from direct assay
10642551 MGI
acts upstream of or within vasculogenesis IDA
IDA: Inferred from direct assay
15611140 MGI
Cellular Component GO Annotation Evidence Reference Source
located in sarcomere IDA
IDA: Inferred from direct assay
16481394 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

troponin I, cardiac muscle

cardiac troponin I

Recombinant Tnni3 Proteins

Cat. No. Product Name Accession Purity
HY-P71469 Cardiac troponin I/Tnni3 Protein, Mouse (His-SUMO) P48787 (2A-211G) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119608 GSK854 Inhibitor 98.40% Unkown
HY-117243 GSK329 Inhibitor 99.60% Unkown
HY-117658 GSK-114 Inhibitor 98.08% Unkown
HY-RS14852 TNNI3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14853 TNNI3K Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnni3 NCBI NCBI:7137