HOXA11 - homeobox A11 Gene

Homo sapiens

Also known as HOX1; HOX1I; RUSAT1

Gene ID: 3207 | Gene type: protein coding

About HOXA11

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,181,157-27,185,232 (from NCBI)

This gene has 2 transcripts (splice variants), 259 orthologues, 42 paralogues and is associated with 44 phenotypes. Biased expression in endometrium (RPKM 34.9), prostate (RPKM 6.8) and 4 other tissues.

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

HOXA11 Products(1)

mRNA	Protein	Name
NM_005523.6	NP_005514.1	homeobox protein Hox-A11

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXA11 Protein Structure

DUF3528

Homeobox

0
100
200
313 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-A11

homeo box 1I

Related Diseases

Diseases

Alias

Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia 1

RUSAT1	Rusat
Thrombocytopenia, Congenital, With Radioulnar Synostosis	Ctrus
Radio-Ulnar Synostosis With Amegakaryocytic Thrombocytopenia	Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia, Type 1
Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia

Radio-Ulnar Synostosis-Amegakaryocytic Thrombocytopenia Syndrome

Atrus Syndrome

Synostosis

Glioma

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Radioulnar Synostosis

Radio-Ulnar Synostosis Type 1

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Thrombocytopenia 1

Xlt	THC1
Thrombocytopenia, X-Linked	Thrombocytopenia, X-Linked, Intermittent
X-Linked Thrombocytopenia	X-Linked Thrombocytopenia With Normal Platelets
Thc	Thrombocytopenia, X-Linked, 1
Thrombocytopenia X-Linked	Thrombocytopenia X-Linked 1

Submucous Uterine Fibroid

Submucous Leiomyoma Of Uterus

Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome	Hfgs
Hfg Syndrome	Hfu Syndrome
HFG	Hfu
Hand Foot Uterus Syndrome	Hand Foot Genital Syndrome

Athabaskan Brainstem Dysgenesis Syndrome

Bosley-Salih-Alorainy Syndrome	Navajo Brainstem Syndrome
ABDS	Human Hoxa1 Syndromes
BSAS	Athabaskan Brainstem Dysgenesis
Bosley Salih Alorainy Syndrome	Absd
Athabascan Brainstem Dysgenesis Syndrome	Narvajo Brainstem Syndrome

Myoma

Muscle Benign Neoplasm	Myomatous Neoplasm
Neoplasms, Muscle Tissue	Benign Neoplasm Of The Muscle
Muscle Neoplasm	Muscle Tissue Neoplasm
Myomatous Tumor	Neoplasm Of Muscle
Muscle Neoplasms	Myomas

Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias

Guttmacher Syndrome	Preaxial Deficiency, Postaxial Polydactyly And Hypospadias
Autosomal Dominant Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias	Preaxial Deficiency-Postaxial Polydactyly-Hypospadias Syndrome
GUTTS

Pelvic Organ Prolapse

Rectal Prolapse	Pelvic Organ Prolapse, Susceptibility To, 1
Pelvic Organ Prolapse, Susceptibility To	Prolapse Of Vagina And Rectum
Vaginal Prolapse	Pelvic Organ Prolapse 1
Procidentia, Rectum	Prolapse Of Rectal Mucosa
Procidentia Of Rectum	Rectal Mucosa Prolapse
Rectum Prolapse	Procidentia Rectum
Rp - [Rectal Prolapse]	Male Proctocele
Male Rectocele	Proctoptosis
Female Genital Prolapse	Female Prolapse
Incompetence Of Pelvic Fundus	Relaxation Of Perineum
Deficiency Of Perineum

Amegakaryocytic Thrombocytopenia, Congenital

Congenital Amegakaryocytic Thrombocytopenia	CAMT
Thrombocytopenia, Congenital Amegakaryocytic	Congenital Amegakaryocytic Thrombocytopenic Purpura
Thrombocytopenia Congenital Amegakaryocytic	Thrombocytopenia, Amegakaryocytic, Congenital

Synpolydactyly

Syndactyly Type 2	Syndactyly, Type 2
Spd

Clubfoot

Congenital Talipes Equinovarus	Congenital Clubfoot
Congenital Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06295	HOXA11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HOXA11	VGNC	VGNC:29909
Mus musculus	HOXA11	MGD	MGI:96172
Canis familiaris	HOXA11	VGNC	VGNC:41746
Felis catus	HOXA11	VGNC	VGNC:67617
Rattus norvegicus	HOXA11	RGD	RGD:1564605
Macaca mulatta	HOXA11	VGNC	VGNC:108412

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