MMP19 - matrix metallopeptidase 19 Gene

Homo sapiens

Also known as CODA; MMP18; RASI-1

Gene ID: 4327 | Gene type: protein coding

About MMP19

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,835,433-55,842,936 (from NCBI)

This gene has 9 transcripts (splice variants), 246 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in gall bladder (RPKM 58.3), appendix (RPKM 21.2) and 19 other tissues.

Summary

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

MMP19 Products(3)

mRNA	Protein	Name
NM_001272101.2	NP_001259030.1	matrix metalloproteinase-19 isoform 3 preproprotein
NM_001414375.1	NP_001401304.1	matrix metalloproteinase-19 isoform 4 preproprotein
NM_002429.6	NP_002420.1	matrix metalloproteinase-19 isoform 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	EXP EXP: Inferred from Experiment	10809722	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP19 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-19

matrix metalloproteinase RASI

Recombinant MMP19 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75929	MMP-19 Protein, Human	Q99542-1 (L101-G256)	≥95%

Related Diseases

Diseases

Alias

Cavitary Optic Disc Anomalies

Familial Cavitary Optic Disc Anomaly	CODA
Familial Coda

Suppurative Periapical Periodontitis

Periapical Abscess	Apical Abscess
Suppurative Apical Periodontitis	Dentoalveolar Abscess
Dental Abscess With Sinus	Dentoalveolar Abscess With Sinus
Dental Sinus	Periapical Abscess Fistula
Apical Tooth Abscess	Apex Abscess
Dental Abscess Nos	Infection Of Tooth Nos
Abscess Of Tooth	Dental Infection Nos

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08536	MMP19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MMP19	MGD	MGI:1927899
Rattus norvegicus	MMP19	RGD	RGD:1311376
Bos taurus	MMP19	VGNC	VGNC:31523
Felis catus	MMP19	VGNC	VGNC:68286
Canis familiaris	MMP19	VGNC	VGNC:43279
Macaca mulatta	MMP19	VGNC	VGNC:74896

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