PALM2AKAP2 - PALM2 and AKAP2 fusion Gene

Homo sapiens

Also known as AKAP2; MISP2; PALM2; PRKA2; AKAP-2; AKAPKL; AKAP-KL; PALM2-AKAP2

Gene ID: 445815 | Gene type: protein coding

About PALM2AKAP2

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:109,640,787-110,172,512 (from NCBI)

This gene has 17 transcripts (splice variants), 107 orthologues and 3 paralogues. Broad expression in fat (RPKM 49.5), lung (RPKM 48.4) and 24 other tissues.

Summary

This gene belongs to the paralemmin downstream gene (PDG) family defined in PMID:22855693. Paralemmin downstream genes may have evolved contiguously with the paralemmin genes and are associated with other paralemmin paralogs in humans and several other taxa. The gene encodes three distinct protein isoforms, the PALM2 isoform, the AKAP2 isoform and the PALM2-AKAP2 isoform. The biological significance of the PALM2-AKAP2 isoforms is yet unknown. Earlier, PALM2 and AKAP2 were annotated as separate genes and PALM2-AKAP2 was annotated as a readthrough gene. [provided by RefSeq, May 2019]

PALM2AKAP2 Products(7)

mRNA	Protein	Name
NM_001004065.4	NP_001004065.2	A-kinase anchor protein 2 isoform 5 (AKAP2)
NM_001037293.3	NP_001032370.1	A-kinase anchor protein 2 isoform 2 (PALM2)
NM_001136562.3	NP_001130034.1	A-kinase anchor protein 2 isoform 7 (AKAP2)
NM_001198656.1	NP_001185585.1	A-kinase anchor protein 2 isoform 6 (AKAP2)
NM_007203.5	NP_009134.1	PALM2-AKAP2 protein isoform 3 (PALM2-AKAP2)
NM_053016.6	NP_443749.5	A-kinase anchor protein 2 isoform 1 (PALM2)
NM_147150.3	NP_671492.1	PALM2-AKAP2 protein isoform 4 (PALM2-AKAP2)

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PALM2AKAP2 Protein Structure

Paralemmin

RII_binding_1

AKAP2_C

0
200
400
600
800
1000
1103 a.a.

Protein Preferred Names

Protein Names

A-kinase anchor protein 2

PALM2-AKAP2 protein

A kinase (PRKA) anchor protein 2

Related Diseases

Diseases

Alias

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10031A	SAR441255 TFA	Agonist	99.65%	Phase 1
HY-P10031	SAR441255	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10379	palm-PrRP31	Agonist	/	Unkown
HY-P10380	palm11-PrRP31	Agonist	/	Unkown
HY-RS10006	PALM2AKAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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