2. GPCR/G Protein
  3. GLP Receptor GCGR
  4. SAR441255 TFA

SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors. SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys.

For research use only. We do not sell to patients.

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SAR441255 TFA Chemical Structure

SAR441255 TFA Chemical Structure

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Other Forms of SAR441255 TFA:

SAR441255 TFA Related Antibodies

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Description

SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors. SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys[1].

IC50 & Target

IC50: GLP-1/GIP/GCG receptor[1]
Molecular Weight

4866.56 (free base)

Formula

C225H3555N57O63.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence Shortening

H-{Aib}-HGTFTSDLSKL-{Lys(γGlu-γGlu-Palm acid)}-EEQRQ-{Aib}-EFIEWLKA-{d-Ala}-GPPS-{Aib}-KPPPK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation
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SAR441255 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR441255SAR 441255SAR-441255GLP ReceptorGCGRGlucagon ReceptorGlucagonmetabolic diseaseobesitytype 2 diabetemonkeyInhibitorinhibitorinhibit

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HY-P10031A
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