SAR441255 TFA

Cat. No.: HY-P10031A Purity: 99.65%: FAQs
Data Sheet SDS COA Handling Instructions

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SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors. SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys.

For research use only. We do not sell to patients.

SAR441255 TFA Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of SAR441255 TFA:

SAR441255 Get quote

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: GLP-1/GIP/GCG receptor^[1]

Molecular Weight

4866.56 (free base)

Formula

C₂₂₅H₃₅₅₅N₅₇O₆₃.xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence Shortening

H-{Aib}-HGTFTSDLSKL-{Lys(γGlu-γGlu-Palm acid)}-EEQRQ-{Aib}-EFIEWLKA-{d-Ala}-GPPS-{Aib}-KPPPK-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 66.67 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (Need ultrasonic)

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (285 KB) SDS (252 KB)

COA (269 KB) RP-HPLC (111 KB) MS (220 KB) Elemental Analysis Report (128 KB)

Handling Instructions (2659 KB)

References

[1]. Martin Bossart, et al. Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. Cell Metab. 2022 Jan 4;34(1):59-74.e10. [Content Brief]

SAR441255 TFA Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR441255SAR 441255SAR-441255GLP ReceptorGCGRGlucagon ReceptorGlucagonmetabolic diseaseobesitytype 2 diabetemonkeyInhibitorinhibitorinhibit

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