2. GPCR/G Protein
  3. GLP Receptor GCGR
  4. SAR441255

SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys.

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Custom Peptide Synthesis

SAR441255 Chemical Structure

SAR441255 Chemical Structure

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Other Forms of SAR441255:

SAR441255 Related Antibodies

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Description

SAR441255 is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 displays high potency with balanced activation of all three target receptors.?SAR441255 shows positive acute glucoregulatory effectss in diabetic obese monkeys[1].

IC50 & Target

IC50: GLP-1/GIP/GCG receptor[1]
Molecular Weight

4866.56

Formula

C225H3555N57O63
Sequence Shortening

H-{Aib}-HGTFTSDLSKL-{Lys(γGlu-γGlu-Palm acid)}-EEQRQ-{Aib}-EFIEWLKA-{d-Ala}-GPPS-{Aib}-KPPPK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (10.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2055 mL 1.0274 mL 2.0548 mL
5 mM 0.0411 mL 0.2055 mL 0.4110 mL
View the Complete Stock Solution Preparation Table

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2055 mL 1.0274 mL 2.0548 mL 5.1371 mL
5 mM 0.0411 mL 0.2055 mL 0.4110 mL 1.0274 mL
10 mM 0.0205 mL 0.1027 mL 0.2055 mL 0.5137 mL
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SAR441255 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR441255SAR 441255SAR-441255GLP ReceptorGCGRGlucagon ReceptorGlucagonmetabolic diseaseobesitytype 2 diabetemonkeyInhibitorinhibitorinhibit

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HY-P10031
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