2. Academic Validation
  3. Safety Assessment of Polyaminopropyl Biguanide (Polyhexamethylene Biguanide Hydrochloride) as Used in Cosmetics

Safety Assessment of Polyaminopropyl Biguanide (Polyhexamethylene Biguanide Hydrochloride) as Used in Cosmetics

  • Int J Toxicol. 2020 Nov/Dec;39(3_suppl):26S-73S. doi: 10.1177/1091581820958683.
Wilbur Johnson Jr 1,  Ivan Boyer 2,  Jinqiu Zhu 3,  Wilma F Bergfeld 4,  Donald V Belsito 4,  Ronald A Hill 4,  Curtis D Klaassen 4,  Daniel C Liebler 4,  James G Marks Jr 4,  Ronald C Shank 4,  Thomas J Slaga 4,  Paul W Snyder 4,  Bart Heldreth 5
Affiliations

Affiliations

  • 1 *  44002Cosmetic Ingredient Review Senior Scientific Analyst/Writer.
  • 2 **  Former 44002Cosmetic Ingredient Review Toxicologist.
  • 3 ***  44002Cosmetic Ingredient Review Toxicologist.
  • 4 ****  Expert Panel for Cosmetic Ingredient Safety Member.
  • 5 †  44002Cosmetic Ingredient Review Executive Director.
PMID: 33203268 DOI: 10.1177/1091581820958683
Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of Polyaminopropyl Biguanide (polyhexamethylene biguanide hydrochloride), which functions as a preservative in cosmetic products. The Panel reviewed relevant data relating to the safety of this ingredient and concluded that Polyaminopropyl Biguanide is safe in cosmetics in the present practices of use and concentration described in the safety assessment, when formulated to be nonirritating and nonsensitizing, which may be based on a quantitative risk assessment or Other accepted methodologies. The Panel also concluded that the data are insufficient to determine the safety of Polyaminopropyl Biguanide in products that may be incidentally inhaled.

Keywords

cosmetics; polyaminopropyl biguanide; polyhexamethylene biguanide hydrochloride; safety.

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