2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. MS-II-124

MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).

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MS-II-124 Chemical Structure

MS-II-124 Chemical Structure

CAS No. : 3037332-85-4

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MS-II-124 Related Antibodies

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Description

MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)[1].

IC50 & Target

IC50=0.12 μM (NLRP3)[1].
In Vivo

MS-II-124 (10 mg/kg; i.p.; single dose) reduces lung inflammation and immune cell infiltration in the LPS (HY-D1056) ( i.n. instillation, 40 μg in 40 μL PBS) -induced ALI/ARDS wild-type mouse model, exhibiting anti-inflammatory and immunomodulatory activities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ALI/ARDS WT C57BL/6 mice model[1].
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), Single dose. 1 h before i.n. instillation of LPS (40 μg in 40 μL PBS).
Result: Significantly inhibited lipopolysaccharide (LPS)-induced IL-1β production in pulmonary bronchoalveolar lavage fluid (BALF), whereas NLRP3 deletion did not significantly inhibit its production.
Molecular Weight

543.05

Formula

C28H28ClFN2O4S
CAS No.
SMILES

ClC1=CC=C(OCCC)C(CN(CCC2=CC=C(S(=O)(NCC#C)=O)C=C2)C(C3=CC=C(F)C=C3)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MS-II-124 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS-II-1243037332-85-4NOD-like Receptor (NLR)acute lung injury (ALI)acute respiratory distress syndrome (ARDS)WT C57BL/6 miceInhibitorinhibitorinhibit

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