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Tnfrsf14

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  • HY-P7366
    HVEM/TNFRSF14 Protein, Human (Sf9, Fc)

    rHuHVEM, Fc Chimera; Tnfrsf14; TR2; CD270; HVEA

    		 Human Sf9 insect cells
    HVEM (herpes virus entry mediator, TNFRSF14, CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM is a bidirectional molecular switch that transduces positive and negative signals. HVEM can deliver proinflammatory and survival signals when engaged by BTLA or LIGHT, stimulating lymphocyte proliferation, activation, and inducing inflammatory reactions. While, HVEM binds to CD160 and BTLA, inhibiting T- and B-lymphocyte activation and proliferation. HVEM/TNFRSF14 Protein, Human (Sf9, Fc) is a recombinant protein consisting of 146 amino acids (L39-K184) and is produced in Sf9 insect cells.
  • HY-P70489
    HVEM/TNFRSF14 Protein, Human (HEK293, His)

    Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; Tnfrsf14; HVEA; HVEM

    		 Human HEK293
    HVEM (herpes virus entry mediator, TNFRSF14, CD270) is a member of the tumor necrosis factor receptor superfamily (TNFRSF). HVEM is a bidirectional molecular switch that transduces positive and negative signals. HVEM can deliver proinflammatory and survival signals when engaged by BTLA or LIGHT, stimulating lymphocyte proliferation, activation, and inducing inflammatory reactions. While, HVEM binds to CD160 and BTLA, inhibiting T- and B-lymphocyte activation and proliferation. HVEM/TNFRSF14 Protein, Human (HEK293, His) is a recombinant protein with a C-Terminal His label, It is produced in HEK293 cells.
  • HY-P700452
    HVEM/TNFRSF14 Protein, Human (HEK293, hFc)

    Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; Tnfrsf14; HVEA; HVEM

    		 Human HEK293
    The HVEM/TNFRSF14 Protein acts as a receptor for four ligands, including TNFSF14/LIGHT, LTA/lymphotoxin-alpha, BTLA, and CD160, forming a complex stimulatory and inhibitory signaling network. Utilizing the TRAF2-TRAF3 E3 ligase pathway, it promotes immune cell survival and differentiation. HVEM participates in bidirectional cell-cell contact signaling and delivers costimulatory signals to T cells in response to TNFSF14/LIGHT ligation. It interacts with CD160 on NK cells, enhancing anti-tumor responses. During bacterial infection, HVEM on epithelial cells responds to CD160, triggering antimicrobial responses. It down-regulates CD28 signaling in activated CD4+ T cells and engages in both cis and trans interactions with BTLA, influencing immune responses. Additionally, HVEM acts as a receptor for Herpes simplex virus 1/HHV-1. HVEM/TNFRSF14 Protein, Human (HEK293, hFc) is the recombinant human-derived HVEM/TNFRSF14 protein, expressed by HEK293, with C-hFc labeled tag. The total length of HVEM/TNFRSF14 Protein, Human (HEK293, hFc) is 164 a.a., with molecular weight of 48.5 kDa.

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