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6-Phosphogluconate dehydrogenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Autophagy (1) Bacterial (3) Endogenous Metabolite (4) Histamine Receptor (4) Immune Checkpoint (1) Influenza Virus (4) Isotope-Labeled Compounds (1) NF-κB (1) SARS-CoV (4) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (8) Endocrinology (4) Infection (5) Inflammation/Immunology (7)

9

Inhibitors & Agonists

6

Natural
Products

2

Recombinant Proteins

1

Isotope-Labeled Compounds

1

Antibodies

Targets Recommended: Succinate Dehydrogenase Glutamate Dehydrogenase (GLDH) Lactate Dehydrogenase Dihydroorotate Dehydrogenase Isocitrate Dehydrogenase (IDH) Methylenetetrahydrofolate Dehydrogenase (MTHFD) Phosphoglycerate Dehydrogenase (PHGDH) Aldehyde Dehydrogenase (ALDH) PDHK 15-PGDH 17β-HSD 11β-HSD

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

6PGD-IN-1 1-Hydroxy-8-methoxyanthraquinone	Immune Checkpoint	Cancer
6PGD-IN-1 (compound S3) is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD). IC₅₀ and K_d the value of 17.8μM and 17.1 μM respectively. 6PGD-IN-1 has antitumor activity .

Physcion-d3 Parietin-d₃; Rheochrysidin-d₃	Isotope-Labeled Compounds Bacterial	Infection Inflammation/Immunology Cancer
Physcion-d₃ (Parietin-d₃) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of **6-phosphogluconate dehydrogenase, with an IC₅₀ and a K_d** of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Ketotifen 3 Publications Verification HC 20-511	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus	Infection Inflammation/Immunology Endocrinology Cancer
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Physcion Maximum Cited Publications 6 Publications Verification Parietin; Rheochrysidin	Bacterial Toll-like Receptor (TLR) NF-κB Apoptosis Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active **6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC₅₀ and K_d values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy** in cancer cells .

Phosphogluconate dehydrogenase (NADP, decarboxylating) 6-Phosphogluconate dehydrogenase	Others	Others
Phosphogluconate dehydrogenase (NADP, decarboxylating) (6-Phosphogluconate dehydrogenase) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Physcion (Standard)	Bacterial	Infection Inflammation/Immunology Cancer
Physcion (Standard) is the analytical standard of Physcion. This product is intended for research and analytical applications. Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively . Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .

Ketotifen fumarate (Standard)	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus	Inflammation/Immunology Endocrinology Cancer
Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Ketotifen (Standard)	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus	Infection Inflammation/Immunology Endocrinology Cancer
Ketotifen (Standard) is the analytical standard of Ketotifen. This product is intended for research and analytical applications. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Cat. No.	Product Name	Category	Target	Chemical Structure

Ketotifen fumarate 3 Publications Verification HC 20511 fumarate	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Ketotifen 3 Publications Verification HC 20-511	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Physcion Maximum Cited Publications 6 Publications Verification Parietin; Rheochrysidin	Structural Classification Classification of Application Fields Polygonaceae Source classification Plants Biological Pesticide Research Agricultural Research Infection Quinones Anthraquinones Rheum officinale Baill. Phenols Polyphenols Inflammation/Immunology Disease Research Fields Cancer	Bacterial Toll-like Receptor (TLR) NF-κB Apoptosis Autophagy Antibiotic
Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active **6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC₅₀ and K_d values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy** in cancer cells .

Physcion (Standard)	Quinones Structural Classification Anthraquinones Polygonaceae Source classification Rheum officinale Baill. Phenols Polyphenols Plants	Bacterial
Physcion (Standard) is the analytical standard of Physcion. This product is intended for research and analytical applications. Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively . Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .

Ketotifen fumarate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Histamine Receptor Endogenous Metabolite SARS-CoV Influenza Virus
Ketotifen (fumarate) (Standard) is the analytical standard of Ketotifen (fumarate). This product is intended for research and analytical applications. Ketotifen (HC 20-511) fumarate is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen fumarate can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen fumarate also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen fumarate can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Ketotifen (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Histamine Receptor SARS-CoV Influenza Virus
Ketotifen (Standard) is the analytical standard of Ketotifen. This product is intended for research and analytical applications. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	PGD Protein, Human (HEK293, His) rHuPGD, His; 6-Phosphogluconate dehydrogenase, decarboxylating; PGD	Human	HEK293
	PGD Protein, Human (HEK293, His) is a homodimeric protein, with an N-terminal His tag. Recombinant Human PGD, His (HEK293-expressed) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP⁺ as cofactor in the pentose phosphate pathway (PPP).

	PGD Protein, Human (His) 6-Phosphogluconate dehydrogenase, decarboxylating; PGD; PGDH	Human	E. coli
	PGD Protein is crucial in cellular metabolism, catalyzing the oxidative decarboxylation of 6-phosphogluconate. This process yields ribulose 5-phosphate, releases CO(2), and simultaneously reduces NADP to NADPH, contributing to essential cellular redox balance. The enzyme's functionality underscores its significance in maintaining cellular homeostasis and participating in key metabolic pathways. PGD Protein, Human (His) is the recombinant human-derived PGD protein, expressed by E. coli , with N-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

Physcion-d3
Physcion-d₃ (Parietin-d₃) is the deuterium labeled Physcion (HY-N0108). Physcion acts as an inhibitor of **6-phosphogluconate dehydrogenase, with an IC₅₀ and a K_d** of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects .

Cat. No.	Compare	Product Name	Application	Reactivity

	PGD Antibody (YA1727) 6-Phosphogluconate dehydrogenase; decarboxylating	WB, ICC/IF, IP	Human, Mouse, Rat
	PGD Antibody (YA1727) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1727), targeting PGD, with a predicted molecular weight of 53 kDa (observed band size: 49 kDa). PGD Antibody (YA1727) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

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