2. Anti-infection Immunology/Inflammation NF-κB Apoptosis Autophagy
  3. Bacterial Toll-like Receptor (TLR) NF-κB Apoptosis Autophagy Antibiotic
  4. Physcion

Physcion  (Synonyms: Parietin; Rheochrysidin)

Cat. No.: HY-N0108 Purity: 99.10%
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Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells.

For research use only. We do not sell to patients.

Physcion Chemical Structure

Physcion Chemical Structure

CAS No. : 521-61-9

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Based on 6 publication(s) in Google Scholar

Other Forms of Physcion:

Physcion Related Antibodies

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Description

Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells[1][2][3][4][5].

IC50 & Target

TLR4

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
A549 IC50
1.5 μM
Compound: 80
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
HCT-116 IC50
19 μM
Compound: 2
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay
[PMID: 17949858]
HepG2 IC50
77.3 μM
Compound: 2
Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay
[PMID: 17949858]
HT-29 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
HUVEC IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
MCF7 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
NCI-H157 IC50
3 μM
Compound: 80
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
In Vitro

Physcion (10 or 20 μM, 48 h) induces apoptosis and autophagy in human nasopharyngeal carcinoma (CNE2 cells)[2].
Physcion (10-40 μM, 24 h) attenuates OGD/R (oxygen-glucose deprivation/reperfusion)-induced neuronal damage and inflammatory response in SH-SY5Y cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Physcion Related Antibodies

Apoptosis Analysis[2]

Cell Line: The nasopharyngeal carcinoma cell line CNE2
Concentration: 10 or 20 μM
Incubation Time: 48 h
Result: Induced apoptosis in CNE2 cells in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: The nasopharyngeal carcinoma cell line CNE2
Concentration: 10 or 20 μM
Incubation Time: 48 h
Result: Significantly increased the level of LC3B-II, which means physcion induced autophagy in CNE2 cells.

Western Blot Analysis[3]

Cell Line: Oxygen-glucose deprivation/reperfusion (OGD/R)-induced SH-SY5Y cells
Concentration: 40 μM
Incubation Time: 24 h
Result: Significantly reversed the OGD/R-induced upregulation of TLR4, p-p65, and p-IκB expression.
In Vivo

Physcion (20 or 40 mg/kg, p.o., once daily for 7 days) exerts neuroprotective effects by inhibiting the TLR4/NF-κB signaling pathway in an ischemia-reperfusion-induced SD rat model[3].
Physcion (4 or 9 mg/kg, p.o., once daily for 6 days) effectively alleviates infection symptoms caused by Chlamydia psittaci 6 BCE in SPF chickens[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats[3]
Dosage: 20 or 40 mg/kg
Administration: Oral gavage (p.o.), once daily for 7 days
Result: Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group.
Obviously decreased areas of infarction compared to I/R group.
Animal Model: SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE[4]
Dosage: 4 or 9 mg/kg
Administration: Oral gavage (p.o.), once daily for 6 days
Result: Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens.
Molecular Weight

284.26

Formula

C16H12O5
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1C2=C(C=C(C)C=C2O)C(C3=CC(OC)=CC(O)=C13)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 3.33 mg/mL (11.71 mM; ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

THF : 2.5 mg/mL (8.79 mM; ultrasonic and warming and heat to 60°C)

DMF : 1 mg/mL (3.52 mM; Need ultrasonic)

Ethanol : < 1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.10%

SDS (393 KB)

COA (250 KB) HNMR (241 KB) RP-HPLC (228 KB) MS (206 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / THF / DMSO 1 mM 3.5179 mL 17.5895 mL 35.1791 mL 87.9477 mL
THF / DMSO 5 mM 0.7036 mL 3.5179 mL 7.0358 mL 17.5895 mL
DMSO 10 mM 0.3518 mL 1.7590 mL 3.5179 mL 8.7948 mL
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Physcion Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Physcion521-61-9Parietin RheochrysidinBacterialToll-like Receptor (TLR)NF-κBApoptosisAutophagyAntibioticNuclear factor-κBNuclear factor-kappaBIschemia-reperfusion (I/R)-induced SD rats modelNasopharyngeal carcinoma cell line CNE2anti-inflammatoryanti-microbialanti-cancerInhibitorinhibitorinhibit

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