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Results for "

AKR1C1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (2) Fluorescent Dye (1) PROTACs (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (1) Neurological Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

AKR1C1-IN-1	Others	Neurological Disease
AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a K_i value of 4 nM for AKR1C1 .

Liquiritin 5 Publications Verification	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology Cancer
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive *AKR1C1* inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

S07-2010	Others	Cancer
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC₅₀ values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, *AKR1C1* and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .

Coumberone	Fluorescent Dye	Cancer
Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C .

AKR1C1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AKR1C1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1C1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKR1C1 Human Pre-designed siRNA Set A AKR1C1 Human Pre-designed siRNA Set A

CPSA	Others	Cancer
CPSA is a potent and competitive inhibitor against 20α-hydroxysteroid dehydrogenase (AKR1C1) with a K_i value of 0.86 nM. CPSA is promising for research of lung and endometrial cancers, premature birth and neuronal disorders .

5-Bromo-3-phenyl salicylic acid	Aldose Reductase	Neurological Disease Cancer
5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with K_i of 140 nM .

PROTAC AKR1C3 degrader-1	PROTACs Aldose Reductase	Cancer
PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610)) .

Liquiritin 5 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Monophenols Flavonoids Leguminosae Flavonones Phenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive *AKR1C1* inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

Cat. No.	Compare	Product Name	Application	Reactivity

	AKR1C1/AKR1C2 Antibody (YA2675) AKR1C1; AKR1C2	WB, FC	Human, Mouse, Rat
	AKR1C1/AKR1C2 Antibody (YA2675) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2675), targeting AKR1C1/AKR1C2, with a predicted molecular weight of 37 kDa (observed band size: 37 kDa). AKR1C1/AKR1C2 Antibody (YA2675) can be used for WB, FC experiment in human, mouse, rat background.

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AKR1C1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AKR1C1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1C1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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