2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Aldose Reductase
  4. PROTAC AKR1C3 degrader-1

PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610)).

For research use only. We do not sell to patients.

PROTAC AKR1C3 degrader-1 Chemical Structure

PROTAC AKR1C3 degrader-1 Chemical Structure

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PROTAC AKR1C3 degrader-1 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610))[1].

In Vitro

PROTAC AKR1C3 degrader-1 (compound 5) (10 nM; 0-72 h) decreases the protein level of AKR1C3, AKR1C1/2, and ARv7 in a time-dependent manner[1].
PROTAC AKR1C3 degrader-1 (0.001, 0.01, 0.1, 1 µM; 72 h) inhibits 22Rv1 cell growth in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC AKR1C3 degrader-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: 22Rv1 cells
Concentration: 10 nM
Incubation Time: 0, 2, 4, 6, 12, 16, 24, 48, 72 h
Result: Decreased the expression of AKR1C3, AKR1C1/2, and ARv7 in a time-dependent manner.
Molecular Weight

841.86

Formula

C45H43N7O10
SMILES

O=C(/C=C/C1=CC(C2=CC=CC=C2)=CC(C(NCC3=CC=C(C=C3)OCC4=CN(N=N4)CCOCCOCC(NC5=CC=CC6=C5CN(C6=O)C7CCC(NC7=O)=O)=O)=O)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC AKR1C3 degrader-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC AKR1C3 degrader-1PROTACsAldose Reductase22Rv1 cellsAKR1C3AKR1C1/2and ARv7prostate cancerInhibitorinhibitorinhibit

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HY-163609
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