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Results for "

AP-4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) HSP (1) iGluR (1) mGluR (6) P2X Receptor (1) P2Y Receptor (1) Potassium Channel (1) Protease Activated Receptor (PAR) (2) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (10)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

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Recombinant Proteins

Oligonucleotides

Targets Recommended: AP-1 AAK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113337A

Ap4A tetraammonium P1,P4-Di-(adenosine-5')-tetrAPhosphate tetraammonium	Apoptosis	Cancer
Ap4A tetraammonium (P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis .

HY-134370

Ap4G	P2X Receptor	Cardiovascular Disease
Ap4G is a dinucleoside polyphosphate compound with vasoconstrictor activity. Ap4G regulates vasoconstriction through P2 receptors, especially P2X receptors, and is an important tool for studying vascular physiology and pathology .

HY-134369

Ap4C tetrasodium	P2Y Receptor	Others Inflammation/Immunology
Ap4C tetrasodium is a dinucleoside polyphosphate containing purine and pyrimidine base moieties. Ap4C tetrasodium acts as a signaling molecule by binding to specific P2Y receptors, activating P2Y2 and *P2Y4* receptors in platelets, leading to platelet aggregation and other cellular responses. Ap4C tetrasodium can be used for research in inflammation and blood coagulation .

HY-162567

AP-4-139B	HSP	Cancer
AP-4-139B is a heat shock protein 70 inhibitor (IC₅₀=180 nM). HSP70 is a protein that is overexpressed in many types of cancer and is closely related to the survival and proliferation of tumor cells. AP-4-139B exhibits significant cytotoxicity to tumor cells, particularly in colorectal cancer cells. AP-4-139B can be used for cancer research .

HY-RS00796

AP4B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP4B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP4B1 Human Pre-designed siRNA Set A AP4B1 Human Pre-designed siRNA Set A

HY-RS00797

AP4E1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP4E1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4E1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP4E1 Human Pre-designed siRNA Set A AP4E1 Human Pre-designed siRNA Set A

HY-RS00798

AP4M1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP4M1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4M1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP4M1 Human Pre-designed siRNA Set A AP4M1 Human Pre-designed siRNA Set A

HY-RS00799

AP4S1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP4S1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4S1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP4S1 Human Pre-designed siRNA Set A AP4S1 Human Pre-designed siRNA Set A

HY-113337

Ap4A P1,P4-Di-(adenosine-5')-tetrAPhosphate	Apoptosis	Cancer
Ap4A (P1,P4-Di-(adenosine-5')-tetraphosphate) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A induces apoptosis .

HY-103549

Z-Cyclopentyl-AP4	mGluR	Neurological Disease
Z-Cyclopentyl-AP4 is a kainate-type glutamate receptor agonist (orthosteric agonist). Z-Cyclopentyl-AP4 is more selective for *mGlu4* than mGlu8 .

HY-100743

DL-AP4 2-Amino-4-phosphonobutyric acid	Others	Neurological Disease Metabolic Disease
DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent K_d of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system .

HY-110070

*DL-AP4* sodium** 2-Amino-4-phosphonobutyric acid sodium	mGluR	Others Neurological Disease
DL-AP4 sodium (2-Amino-4-phosphonobutyric acid sodium) is an agonist for metabotropic glutamate receptors (mGluR). DL-AP4 sodium binds to mGluR4, activates the signaling pathway that is negatively correlated with adenylate cyclase, and inhibits the Forskolin (HY-15371)-induced production of cAMP. DL-AP4 sodium is also an inhibitor for ON channel, that reduces the sensitivity of photoreceptors to brightness changes .

HY-100781

D-AP4 D-APB; D-2-Amino-4-phosphonobutyric acid	iGluR	Neurological Disease
D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co ²⁺ influx in cultured cerebellar granule cells (IC₅₀ ≥ 100 μM) .

HY-100781A

L-AP4 L-APB	mGluR	Neurological Disease
L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively .

HY-100781B

*L-AP4* monohydrate** L-APB monohydrate	mGluR	Neurological Disease
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively .

HY-101226

MSOP	mGluR	Neurological Disease
MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent K_D of 51 μM for the L-AP4-sensitive presynaptic mGluR.

HY-101241

MPPG	mGluR	Neurological Disease
MPPG is a potent and selective *L-AP4*-sensitive receptor antagonist with an k_D value of 9.2 μM, being tested on the neonatal rat spinal cord .

HY-163329

BCH-HSP-C01	Others	Neurological Disease
BCH-HSP-C01 is a lead compound that restores AP-4-dependent protein trafficking in neuronal models of adapter protein complex 4 (AP-4)-associated hereditary spastic paraplegia. BCH-HSP-C01 can be used for the research of autophagy-associated diseases .

HY-108578

RuBi-4AP	Potassium Channel	Neurological Disease
RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged K_v channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .

HY-133597

4-Chlorocatechol	Others	Others
4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP). 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase .

HY-P1309

PAR-4 Agonist Peptide, amide 2 Publications Verification PAR-4-AP; AY-NH2	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

HY-P1309A

PAR-4 Agonist Peptide, amide TFA 2 Publications Verification PAR-4-AP TFA; AY-NH2 TFA	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist .

Cat. No.	Product Name	Target	Research Area

HY-P1309

PAR-4 Agonist Peptide, amide 2 Publications Verification PAR-4-AP; AY-NH2	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

HY-P1309A

PAR-4 Agonist Peptide, amide TFA 2 Publications Verification PAR-4-AP TFA; AY-NH2 TFA	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113337

Ap4A P1,P4-Di-(adenosine-5')-tetrAPhosphate	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Apoptosis
Ap4A (P1,P4-Di-(adenosine-5')-tetraphosphate) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A induces apoptosis .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P77108

	NUDT2 Protein, Human (His) Bis(5'-nucleosyl)-tetrAPhosphatase [asymmetrical]; AP4Aase; Nudix motif 2; APAH1	Human	E. coli
	The NUDT2 protein has a dual enzymatic role as a catalyst for the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to generate AMP and ATP. This activity highlights its involvement in nucleotide metabolism and the regulation of cellular purine nucleotide pools. NUDT2 Protein, Human (His) is the recombinant human-derived NUDT2 protein, expressed by E. coli , with N-His labeled tag. The total length of NUDT2 Protein, Human (His) is 147 a.a., with molecular weight of ~18.3 kDa.

HY-P703450

	*L-AP4* Protein, Human** Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513); Aminopeptidase; Hydrolase; Protease	Human	E. coli

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AP4B1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AP4B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP4E1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AP4E1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4E1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP4M1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AP4M1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4M1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP4S1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AP4S1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4S1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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