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Results for "

AP-4

" in MedChemExpress (MCE) Product Catalog:

22

Inhibitors & Agonists

2

Peptides

1

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2

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4

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134370

    P2X Receptor Cardiovascular Disease
    Ap4G is a dinucleoside polyphosphate compound with vasoconstrictor activity. Ap4G regulates vasoconstriction through P2 receptors, especially P2X receptors, and is an important tool for studying vascular physiology and pathology .
    Ap4G
  • HY-134369

    P2Y Receptor Others Inflammation/Immunology
    Ap4C tetrasodium is a dinucleoside polyphosphate containing purine and pyrimidine base moieties. Ap4C tetrasodium acts as a signaling molecule by binding to specific P2Y receptors, activating P2Y2 and P2Y4 receptors in platelets, leading to platelet aggregation and other cellular responses. Ap4C tetrasodium can be used for research in inflammation and blood coagulation .
    Ap4C tetrasodium
  • HY-162567

    HSP Cancer
    AP-4-139B is a heat shock protein 70 inhibitor (IC50=180 nM). HSP70 is a protein that is overexpressed in many types of cancer and is closely related to the survival and proliferation of tumor cells. AP-4-139B exhibits significant cytotoxicity to tumor cells, particularly in colorectal cancer cells. AP-4-139B can be used for cancer research .
    AP-4-139B
  • HY-RS00796

    Small Interfering RNA (siRNA) Others

    AP4B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AP4B1 Human Pre-designed siRNA Set A
    AP4B1 Human Pre-designed siRNA Set A
  • HY-RS00797

    Small Interfering RNA (siRNA) Others

    AP4E1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4E1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AP4E1 Human Pre-designed siRNA Set A
    AP4E1 Human Pre-designed siRNA Set A
  • HY-RS00798

    Small Interfering RNA (siRNA) Others

    AP4M1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4M1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AP4M1 Human Pre-designed siRNA Set A
    AP4M1 Human Pre-designed siRNA Set A
  • HY-RS00799

    Small Interfering RNA (siRNA) Others

    AP4S1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP4S1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AP4S1 Human Pre-designed siRNA Set A
    AP4S1 Human Pre-designed siRNA Set A
  • HY-113337

    P1,P4-Di-(adenosine-5')-tetrAPhosphate

    Apoptosis Cancer
    Ap4A (P1,P4-Di-(adenosine-5')-tetraphosphate) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A induces apoptosis .
    Ap4A
  • HY-113337A

    P1,P4-Di-(adenosine-5')-tetrAPhosphate tetraammonium

    Apoptosis Cancer
    Ap4A tetraammonium (P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis .
    Ap4A tetraammonium
  • HY-103549

    mGluR Neurological Disease
    Z-Cyclopentyl-AP4 is a kainate-type glutamate receptor agonist (orthosteric agonist). Z-Cyclopentyl-AP4 is more selective for mGlu4 than mGlu8 .
    Z-Cyclopentyl-AP4
  • HY-100743

    2-Amino-4-phosphonobutyric acid

    Others Neurological Disease Metabolic Disease
    DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system .
    DL-AP4
  • HY-110070

    2-Amino-4-phosphonobutyric acid sodium

    mGluR Others Neurological Disease
    DL-AP4 sodium (2-Amino-4-phosphonobutyric acid sodium) is an agonist for metabotropic glutamate receptors (mGluR). DL-AP4 sodium binds to mGluR4, activates the signaling pathway that is negatively correlated with adenylate cyclase, and inhibits the Forskolin (HY-15371)-induced production of cAMP. DL-AP4 sodium is also an inhibitor for ON channel, that reduces the sensitivity of photoreceptors to brightness changes .
    DL-AP4 sodium
  • HY-100781

    D-APB; D-2-Amino-4-phosphonobutyric acid

    iGluR Neurological Disease
    D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co 2+ influx in cultured cerebellar granule cells (IC50 ≥ 100 μM) .
    D-AP4
  • HY-100781A

    L-APB

    mGluR Neurological Disease
    L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively .
    L-AP4
  • HY-100781B

    L-APB monohydrate

    mGluR Neurological Disease
    L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively .
    L-AP4 monohydrate
  • HY-101226

    mGluR Neurological Disease
    MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.
    MSOP
  • HY-101241

    mGluR Neurological Disease
    MPPG is a potent and selective L-AP4-sensitive receptor antagonist with an kD value of 9.2 μM, being tested on the neonatal rat spinal cord .
    MPPG
  • HY-163329

    Others Neurological Disease
    BCH-HSP-C01 is a lead compound that restores AP-4-dependent protein trafficking in neuronal models of adapter protein complex 4 (AP-4)-associated hereditary spastic paraplegia. BCH-HSP-C01 can be used for the research of autophagy-associated diseases .
    BCH-HSP-C01
  • HY-108578

    Potassium Channel Neurological Disease
    RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged Kv channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .
    RuBi-4AP
  • HY-133597

    Others Others
    4-Chlorocatechol is a major degradation product of 4-chloro-2-aminophenol (4C2AP). 4-Chlorocatechol is also a substrate for catechol 1,2-dioxygenases and chlorocatechol dioxygenase .
    4-Chlorocatechol
  • HY-P1309
    PAR-4 Agonist Peptide, amide
    2 Publications Verification

    PAR-4-AP; AY-NH2

    Protease Activated Receptor (PAR) Inflammation/Immunology
    PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.
    PAR-4 Agonist Peptide, amide
  • HY-P1309A
    PAR-4 Agonist Peptide, amide TFA
    2 Publications Verification

    PAR-4-AP TFA; AY-NH2 TFA

    Protease Activated Receptor (PAR) Inflammation/Immunology
    PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist .
    PAR-4 Agonist Peptide, amide TFA

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