2. Apoptosis
  3. Apoptosis
  4. Ap4A tetraammonium

Ap4A tetraammonium  (Synonyms: P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium)

Cat. No.: HY-113337A Purity: ≥97.0%
COA Handling Instructions

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Ap4A tetraammonium (P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis.

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Ap4A tetraammonium Chemical Structure

Ap4A tetraammonium Chemical Structure

CAS No. : 102783-36-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Ap4A tetraammonium:

Ap4A tetraammonium Related Antibodies

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Description

Ap4A tetraammonium (P1,P4-Di-(adenosine-5')-tetraphosphate tetraammonium) is a conserved second messenger in organisms ranging from bacteria to humans. Ap4A tetraammonium binds to the histidine triad nucleotide-binding protein 1 (HINT1) activates the transcription of genes downstream of MITF. Ap4A tetraammonium induces apoptosis[1][2].

In Vitro

Ap4A tetraammonium (1, 10 µM; 24 h) induces apoptosis in HL60 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ap4A tetraammonium Related Antibodies
Molecular Weight

904.51

Formula

C20H40N14O19P4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OP(OP(OC[C@H]4O[C@@H](N5C=NC6=C5N=CN=C6N)[C@H](O)[C@@H]4O)(O)=O)(O)=O)(O)=O)(O)=O.N.N.N.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (55.28 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1056 mL 5.5279 mL 11.0557 mL
5 mM 0.2211 mL 1.1056 mL 2.2111 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1056 mL 5.5279 mL 11.0557 mL 27.6393 mL
5 mM 0.2211 mL 1.1056 mL 2.2111 mL 5.5279 mL
10 mM 0.1106 mL 0.5528 mL 1.1056 mL 2.7639 mL
15 mM 0.0737 mL 0.3685 mL 0.7370 mL 1.8426 mL
20 mM 0.0553 mL 0.2764 mL 0.5528 mL 1.3820 mL
25 mM 0.0442 mL 0.2211 mL 0.4422 mL 1.1056 mL
30 mM 0.0369 mL 0.1843 mL 0.3685 mL 0.9213 mL
40 mM 0.0276 mL 0.1382 mL 0.2764 mL 0.6910 mL
50 mM 0.0221 mL 0.1106 mL 0.2211 mL 0.5528 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ap4A tetraammonium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ap4A tetraammonium102783-36-8P1,P4-Di-(adenosine-5')-tetraphosphate tetraammoniumApoptosisRBL cellsHINT1 polymerizationapoptosisHL60 cellsInhibitorinhibitorinhibit

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