1. GPCR/G Protein Neuronal Signaling
  2. mGluR
  3. L-AP4 monohydrate

L-AP4 monohydrate  (Synonyms: L-APB monohydrate)

Cat. No.: HY-100781B Purity: ≥99.0%
Data Sheet SDS COA Handling Instructions

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.

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L-AP4 monohydrate Chemical Structure

L-AP4 monohydrate Chemical Structure

CAS No. : 2247534-79-6

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  • Purity & Documentation

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Description

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].

IC50 & Target[1]

mGlu4

0.13 μM (EC50)

mGlu8

0.29 μM (EC50)

mGlu6

1.0 μM (EC50)

mGlu7

249 μM (EC50)

In Vivo

L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats.[2]
Dosage: 5-30 μg.
Administration: Intrathecal inhection 4-5 days.
Result: Dose-dependently increased paw withdrawal threshold.
Molecular Weight

201.11

Formula

C4H12NO6P

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCP(O)(O)=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (49.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9724 mL 24.8620 mL 49.7240 mL
5 mM 0.9945 mL 4.9724 mL 9.9448 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9724 mL 24.8620 mL 49.7240 mL 124.3101 mL
5 mM 0.9945 mL 4.9724 mL 9.9448 mL 24.8620 mL
10 mM 0.4972 mL 2.4862 mL 4.9724 mL 12.4310 mL
15 mM 0.3315 mL 1.6575 mL 3.3149 mL 8.2873 mL
20 mM 0.2486 mL 1.2431 mL 2.4862 mL 6.2155 mL
25 mM 0.1989 mL 0.9945 mL 1.9890 mL 4.9724 mL
30 mM 0.1657 mL 0.8287 mL 1.6575 mL 4.1437 mL
40 mM 0.1243 mL 0.6216 mL 1.2431 mL 3.1078 mL
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