L-AP4 monohydrate (Synonyms: L-APB monohydrate)

Cat. No.: HY-100781B Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively.

For research use only. We do not sell to patients.

L-AP4 monohydrate Chemical Structure

CAS No. : 2247534-79-6

Size	Price	Stock
5 mg	USD 260	Ask For Quote & Lead Time
10 mg	USD 450	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of L-AP4 monohydrate:

D-AP4 Get quote
L-AP4 Get quote

1 Publications Citing Use of MCE L-AP4 monohydrate

•Biochem Biophys Res Commun. 2020 Dec 17;533(4):1393-1399. [Abstract]

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mGluR Isoform Specific Products:

View All Isoforms

mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

mGlu₄

0.13 μM (EC₅₀)

mGlu8

0.29 μM (EC₅₀)

mGlu₆

1.0 μM (EC₅₀)

mGlu7

249 μM (EC₅₀)

In Vivo

L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction^[2].
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats^[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats.^[2]
Dosage:	5-30 μg.
Administration:	Intrathecal inhection 4-5 days.
Result:	Dose-dependently increased paw withdrawal threshold.

Molecular Weight

201.11

Formula

C₄H₁₂NO₆P

CAS No.

2247534-79-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCP(O)(O)=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (49.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9724 mL	24.8620 mL	49.7240 mL
5 mM	0.9945 mL	4.9724 mL	9.9448 mL
10 mM	0.4972 mL	2.4862 mL	4.9724 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (248 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

References

[1]. Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. [Content Brief]

[2]. Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.9724 mL	24.8620 mL	49.7240 mL	124.3101 mL
	5 mM	0.9945 mL	4.9724 mL	9.9448 mL	24.8620 mL
	10 mM	0.4972 mL	2.4862 mL	4.9724 mL	12.4310 mL
	15 mM	0.3315 mL	1.6575 mL	3.3149 mL	8.2873 mL
	20 mM	0.2486 mL	1.2431 mL	2.4862 mL	6.2155 mL
	25 mM	0.1989 mL	0.9945 mL	1.9890 mL	4.9724 mL
	30 mM	0.1657 mL	0.8287 mL	1.6575 mL	4.1437 mL
	40 mM	0.1243 mL	0.6216 mL	1.2431 mL	3.1078 mL

L-AP4 monohydrate Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-AP42247534-79-6L-APBmGluRMetabotropic glutamate receptorswithdrawalthresholdMetabotropicGlutamateneuronInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks