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Aristolochic acid A

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By Targets:	Apoptosis (3) Aryl Hydrocarbon Receptor (1) Biochemical Assay Reagents (1) Caspase (2) NF-κB (2) Phospholipase (2)
By Research Areas:	Cancer (9) Inflammation/Immunology (3) Neurological Disease (1)

16

Inhibitors & Agonists

1

Biochemical Assay Reagents

14

Natural
Products

Targets Recommended: Amino acid Transporter Amino Acid Derivatives Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Aristolochic acid A Maximum Cited Publications 9 Publications Verification Aristolochic acid I; TR 1736	NF-κB	Cancer
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

Aristolochic acid B 1 Publications Verification	Others	Cancer
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

Aristolochic acid D	Others	Cancer
Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

Aristolochic acid C	Phospholipase	Cancer
Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A₂ (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

7-Hydroxyaristolochic acid A	Others	Inflammation/Immunology
7-Hydroxyaristolochic acid A is an aristolochic acid analogue found in Aristolochia plants. Aristolochic acid can be used as an anti-inflammatory agent .

Aristolochic acid A (Standard)	NF-κB	Cancer
Aristolochic acid A (Standard) is the analytical standard of Aristolochic acid A. This product is intended for research and analytical applications. Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

Aristolochic acid D (Standard)	Others	Cancer
Aristolochic acid D (Standard) is the analytical standard of Aristolochic acid D. This product is intended for research and analytical applications. Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

Aristolochic acid B (Standard)	Others	Cancer
Aristolochic acid B (Standard) is the analytical standard of Aristolochic acid B. This product is intended for research and analytical applications. Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

Aristolochic acid C (Standard)	Phospholipase	Cancer
Aristolochic acid C (Standard) is the analytical standard of Aristolochic acid C. This product is intended for research and analytical applications. Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

Aristolochic acid Va	Others	Others
Aristolochic acid Va is a natural compound that can be isolated from Aristolochia plants .

Aristolochic acid III	Others	Others
Aristolochic acid III is a natural product that can be isolated from the leaves of Aristolochia debilis .

Aristololactam II	Others	Others
Aristololactam II, a metabolite of Aristolochic acid II (AAII), is an excretion product found in the urine, which is considered to be detoxification metabolite of AAII .

Aristolochic acid sodium salt Maximum Cited Publications 9 Publications Verification Aristolochic acid I sodium; TR 1736 sodium; Sodium aristolochate	Biochemical Assay Reagents	Others
Aristolochic acid sodium salt (Sodium aristolate 1) is a component of some Chinese herbal medicines and is responsible for nephrotoxicity. It is a proagent that is activated by reduction of nitro groups to amines, resulting in the formation of cytotoxic DNA adducts.

Aristolactam I 1 Publications Verification Aristololactam; Aristolactam	Caspase Apoptosis	Inflammation/Immunology
Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway .

Aristolactam I (Standard)	Caspase Apoptosis	Inflammation/Immunology
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway .

β-Naphthoflavone 1 Publications Verification 5,6-Benzoflavone; beta-NF	Aryl Hydrocarbon Receptor Apoptosis	Neurological Disease Cancer
β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to treat aristolochic acid (AAI) induced renal injury .

Cat. No.	Product Name	Type

Aristolochic acid sodium salt 5+ Cited Publications Aristolochic acid I sodium; TR 1736 sodium; Sodium aristolochate	Biochemical Assay Reagents
Aristolochic acid sodium salt (Sodium aristolate 1) is a component of some Chinese herbal medicines and is responsible for nephrotoxicity. It is a proagent that is activated by reduction of nitro groups to amines, resulting in the formation of cytotoxic DNA adducts.

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