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Bcl-2/Mcl-1-IN-2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129700
    MCL-1/BCL-2-IN-2

    		Bcl-2 Family Cancer
    MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor .
    MCL-1/BCL-2-IN-2
  • HY-12020
    TW-37
    2 Publications Verification

    		 Bcl-2 Family Cancer
    TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively.
    TW-37
  • HY-129701
    MCL-1/BCL-2-IN-3

    		Bcl-2 Family Cancer
    MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively .
    MCL-1/BCL-2-IN-3
  • HY-125876
    PROTAC Bcl2 degrader-1
    1 Publications Verification

    		 PROTACs Bcl-2 Family Cancer
    PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).
    PROTAC Bcl2 degrader-1
  • HY-129681
    MCL-1/BCL-2-IN-1

    		Bcl-2 Family Cancer
    MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively .
    MCL-1/BCL-2-IN-1
  • HY-125877
    PROTAC Mcl1 degrader-1
    1 Publications Verification

    		 PROTACs Bcl-2 Family Cancer
    PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM .
    PROTAC Mcl1 degrader-1
  • HY-144428
    Bcl-2/Mcl-1-IN-2

    		Bcl-2 Family Cancer
    Bcl-2/Mcl-1-IN-2 (compound 2) is a Bcl-2/Mcl-1 inhibitor, with Kis of 0.88 μM and 4.70 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-2 can be used for the research of cancer .
    Bcl-2/Mcl-1-IN-2
  • HY-129702
    MCL-1/BCL-2-IN-4

    		Bcl-2 Family Cancer
    MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor .
    MCL-1/BCL-2-IN-4
  • HY-13408
    (+)-Apogossypol

    Apogossypol; NSC736630

    		 Bcl-2 Family Cancer
    (+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.
    (+)-Apogossypol
  • HY-128360
    dMCL1-2

    		PROTACs Bcl-2 Family Apoptosis Cancer
    dMCL1-2 is a potent and selective PROTAC of myeloid cell leukemia 1 (MCL1) (Bcl-2 family member) based on Cereblon, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1 .
    dMCL1-2
  • HY-115529
    (-)BI97D6

    		Bcl-2 Family Apoptosis Cancer
    (-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values ​​of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells .
    (-)BI97D6

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