2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. (-)BI97D6

(-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values ​​of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells.

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(-)BI97D6 Chemical Structure

(-)BI97D6 Chemical Structure

CAS No. : 1430067-36-9

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(-)BI97D6 Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

(-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values ​​of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells[1].

IC50 & Target[1]

Bcl-xL

0.076 μM (IC50)

Mcl-1

0.025 μM (IC50)

Bcl-2

0.031 μM (IC50)

Bcl-1

0.122 μM (IC50)

Molecular Weight

586.59

Formula

C36H26O8
CAS No.
SMILES

O=C1C2=CC(O)=C(C(CC3=CC=CC=C3)=C2C(C(C)=C1C(C(C4=CC(O)=C(C(CC5=CC=CC=C5)=C46)O)=O)=C(C)C6=O)=O)O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(-)BI97D6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)BI97D61430067-36-9Bcl-2 FamilyApoptosisBCL-2 protein familyinhibitormitochondriaapoptosisAMLInhibitorinhibit

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