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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

C2C12 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Androgen Receptor (1) Apoptosis (1) Calcium Channel (1) Endogenous Metabolite (4) ERK (2) Estrogen Receptor/ERR (1) GSK-3 (1) Histone Methyltransferase (1) JNK (1) NF-κB (2) P2Y Receptor (1) Phosphatase (1) Phosphodiesterase (PDE) (1) PI3K (1) PPAR (2) Reactive Oxygen Species (3) REV-ERB (1) ROS Kinase (1) Sirtuin (1) TGF-beta/Smad (1) TGF-β Receptor (1) YAP (1) β-catenin (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (5) Infection (3) Inflammation/Immunology (4) Metabolic Disease (9) Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112821

IBS008738	YAP	Inflammation/Immunology
IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model .

HY-128591

DIPQUO 1 Publications Verification	Phosphatase	Metabolic Disease
DIPQUO is an activator of the bone marker alkaline phosphatase (ALP), with an EC₅₀ of 6.27 μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β .

HY-W025074

BML-278	Sirtuin Histone Methyltransferase	Cancer
BML-278 is a SIRT1 activator (EC₁₅₀: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts .

HY-112820

Chlorantraniliprole 1 Publications Verification	Calcium Channel Others	Others
Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC₅₀s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ～300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC₅₀, 14 μM).

HY-113071A

Mevalonic acid lithium salt Maximum Cited Publications 8 Publications Verification MVA lithium salt	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .

HY-126026

NF-κB-IN-17	NF-κB	Inflammation/Immunology
NF-κB-IN-17 (Zinc5) is a NF-κB inhibitor. NF-κB-IN-17 inhibits TNF-α-induced NF-κB DNA binding activity in C2C12 cells .

HY-136395

Cartap	Reactive Oxygen Species	Infection
Cartap, an organonitrogen insecticide, can cause a marked irreversible Ca ²⁺-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms. Cartap significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells .

HY-W040028

Cartap hydrochloride	Reactive Oxygen Species	Infection
Cartap hydrochloride, an organonitrogen insecticide, can cause a marked irreversible Ca ²⁺-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms. Cartap hydrochloride significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells .

HY-113071

Mevalonic acid MVA	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .

HY-113071C

(S)-Mevalonic acid (S)-MVA	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease
(S)-Mevalonic acid is the isomer of Mevalonic acid (HY-113071). Mevalonic acid ((S)-DCIT) is a precursor substance of the mevalonate pathway，which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .

HY-108440

Shz-1	Others	Cardiovascular Disease
Shz-1, a small cardiogenic molecule, induces various cardiac-specific genes including sarcomeric tropomyosin in P19CL6 cells. Shz-1 induces Nkx2.5 expression in mouse. Shz-1 activates the axolotl TPM4 promoter-driven ectopic expression in C2C12 cells .

HY-W040028R

Cartap hydrochloride (Standard)	Reactive Oxygen Species	Infection
Cartap (hydrochloride) (Standard) is the analytical standard of Cartap (hydrochloride). This product is intended for research and analytical applications. Cartap hydrochloride, an organonitrogen insecticide, can cause a marked irreversible Ca2+-dependent contracture in both isolated mouse and rabbit phrenic nerve-diaphragms. Cartap hydrochloride significantly increases the level of endogenous reactive oxygen species (ROS) in C2C12 cells .

HY-112820R

Chlorantraniliprole (Standard)	Others	Others
Chlorantraniliprole (Standard) is the analytical standard of Chlorantraniliprole. This product is intended for research and analytical applications. Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC₅₀s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ～300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC₅₀, 14 μM).

HY-113071AR

Mevalonic acid lithium salt (Standard)	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease
Mevalonic acid (lithium salt) (Standard) is the analytical standard of Mevalonic acid (lithium salt). This product is intended for research and analytical applications. Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .

HY-125026

MyomiRs-IN-1	Others	Others
MyomiRs-IN-1 is a myomiRs inhibitor with activity to inhibit myoD translation in C2C12 cells. MyomiRs-IN-1 does not change the expression level of myoD mRNA, while downregulating the expression of differentiation markers. MyomiRs-IN-1 affects the expression of myomiRs in muscle cells by regulating the regulatory pathway between miR-221/222 and myoD. The application of MyomiRs-IN-1 can facilitate research on muscle development and related diseases .

HY-155705

BMP agonist 1	TGF-β Receptor GSK-3 β-catenin	Others
BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research .

HY-150795

SY-LB-35	TGF-beta/Smad PI3K Akt ERK JNK	Others
SY-LB-35 is a potent bone morphogenetic protein (BMP) receptor agonist. SY-LB-35 can stimulate significant increases in cell number and cell viability in the C2C12 myoblast cell line, and causes shifts towards the S and G2/M phases of the cell cycle. SY-LB-35 stimulates canonical Smad and non-canonical PI3K/Akt, ERK, p38 and JNK intracellular signaling pathways .

HY-117356A

MRS2693 ammonium	P2Y Receptor NF-κB ERK Apoptosis	Inflammation/Immunology
MRS2693 ammonium is the ammonium dalt form of MRS2693 (HY-117356). MRS2693 ammonium is a selective agonist for P2Y6 with an EC₅₀ of 0.015 μM. MRS2693 ammonium protects C2C12 skeletal muscle cells from TNFα-induced apoptosis. MRS2693 ammonium reduces the activation of NF-kB, activates the ERK1/2 pathway, and has a cytoprotective effect on mouse ischemia-reperfusion injury model [2].

HY-100990

MMPX	Phosphodiesterase (PDE)	Neurological Disease
MMPX is a potent PDE1 inhibitor .

HY-13273

Ostarine 2 Publications Verification MK-2866; GTX-024; Enobosarm	Androgen Receptor	Others Cancer
Ostarine (MK-2866) is a selective androgen receptor modulator (SARMs) that regulates cardiomyocyte function, improves bone healing, regulates uterine function, and influences muscle tissue metabolism .

HY-155673

SLU-PP-332	Estrogen Receptor/ERR	Metabolic Disease
SLU-PP-332 is a pan-Estrogen Receptor/ERR agonist with EC₅₀ values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 has the potential to study metabolic diseases as well as improve muscle function .

HY-148922

PPARα/γ agonist 2	PPAR	Metabolic Disease
PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC₅₀ values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent .

HY-130278

MitoPQ 2 Publications Verification MitoParaquat	ROS Kinase	Cancer
MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study .

HY-148711

STL1267 1 Publications Verification	REV-ERB	Metabolic Disease Inflammation/Immunology Cancer
STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a K_i value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1 .

HY-162578

PPARα/γ agonist 4	PPAR	Metabolic Disease
PPARα/γ agonist 4 (Compound (S)-7) is an orally active dual potent agonist of PPARα and PPARγ, with EC₅₀ values of 0.061 μM and 1.42 μM respectively. PPARα/γ agonist 4 acts through an insulin-independent mechanism and exhibits mitochondrial pyruvate carrier inhibition and anti-diabetic properties. PPARα/γ agonist 4 is expected to be used in research for dyslipidemic type 2 diabetes .

Mevalonic acid lithium salt 5+ Cited Publications MVA lithium salt	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .

Mevalonic acid MVA	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .

Mevalonic acid lithium salt (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Mevalonic acid (lithium salt) (Standard) is the analytical standard of Mevalonic acid (lithium salt). This product is intended for research and analytical applications. Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .

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C2C12 cells

Inhibitors & Agonists

NaturalProducts

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