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Results for "

CLL1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (2) Btk (3) EGFR (1) Epigenetic Reader Domain (5) FLT3 (2) PROTAC-Linker Conjugates for PAC (3) PROTACs (5) Syk (2)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138635

PROTAC BRD4 Degrader-12	PROTACs PROTAC-Linker Conjugates for PAC Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC₅₀ of 0.39 nM and 0.24 nM, respectively ^[1].

HY-138633

PROTAC BRD4 Degrader-10	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-10 (compound 8b) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC₅₀ of 1.3 nM and 18 nM, respectively ^[1].

HY-138632

PROTAC BRD4 Degrader-9	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-9 (compound 8a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC₅₀ of 0.86 nM and 7.6 nM, respectively ^[1].

HY-138634

PROTAC BRD4 Degrader-11	PROTACs PROTAC-Linker Conjugates for PAC Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-11 (compound 9a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC₅₀ of 0.23 nM and 0.38 nM, respectively ^[1].

HY-122562

MT-802 1 Publications Verification	PROTACs Btk	Inflammation/Immunology Cancer
MT-802 is a potent BTK degrader based on Cereblon ligand, with a DC₅₀ of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL) .

HY-114367

Delphinidin 3-rutinoside chloride Delphinidin 3-O-rutinoside chloride	Apoptosis	Cancer
Delphinidin 3-rutinoside chloride (Delphinidin 3-O-rutinoside chloride) is an active anthocyanin found in Solanum melongena. Delphinidin 3-rutinoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL) . Delphinidin 3-rutinoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC₅₀ of 2.3 μM .

HY-100867A

Mivavotinib monohydrochloride TAK-659 monohydrochloride; CB-659 monohydrochloride	Syk FLT3	Cancer
TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC₅₀ of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-17600

Acalabrutinib 20+ Cited Publications ACP-196	Btk	Cancer
Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138636

PROTAC BRD4 Degrader-13	PROTAC-Linker Conjugates for PAC Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-13 (compound 9d) is a von Hippel-Lindau system-based PROTAC BRD4 degrader with a linker that can be coupled to ADC antibodies to form PACs (PROTAC-antibody Conjugates). PROTAC BRD4 Degrader-13 can be coupled to STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC₅₀ values of 0.025 nM and 6.0 nM, respectively ^[1].

HY-100867

Mivavotinib TAK-659; CB-659	Syk FLT3	Cancer
TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC₅₀ of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL) .

HY-17600R

Acalabrutinib (Standard)	Btk	Cancer
Acalabrutinib (Standard) is the analytical standard of Acalabrutinib. This product is intended for research and analytical applications. Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL) . Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-108052

Delphinidin 3-glucoside chloride Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride	EGFR Apoptosis Akt	Cardiovascular Disease Cancer
Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL) . Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC₅₀ of 9.7 μM . Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC₅₀ of 2.37 µM . Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction .

Delphinidin 3-rutinoside chloride Delphinidin 3-O-rutinoside chloride	Structural Classification Anthocyans Flavonoids Classification of Application Fields Solanum melongena L. Source classification Phenols Polyphenols Plants Solanaceae Disease Research Fields Cancer	Apoptosis
Delphinidin 3-rutinoside chloride (Delphinidin 3-O-rutinoside chloride) is an active anthocyanin found in Solanum melongena. Delphinidin 3-rutinoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL) . Delphinidin 3-rutinoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC₅₀ of 2.3 μM .

Delphinidin 3-glucoside chloride Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride	Malvaceae Structural Classification Anthocyans Flavonoids Microorganisms Classification of Application Fields Hibiscus sabdariffa Linn. Source classification Plants Disease Research Fields Cancer	EGFR Apoptosis Akt
Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL) . Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC₅₀ of 9.7 μM . Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC₅₀ of 2.37 µM . Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction .

Recombinant Proteins Recommended:

CLL-1

Species:	Human (6) Mouse (2) Cynomolgus (2)
Tag:	His (5) Avi (3) Fc (5)
Source:	HEK293 (10)

Cat. No.	Compare	Product Name	Species	Source

HY-P76845

	CL-L1/COLEC10 Protein, Mouse (HEK293, Fc) Collectin-10; Collectin liver protein 1; CL-L1	Mouse	HEK293
	CL-L1/COLEC10, operating as a lectin, displays distinct sugar-binding preferences, with a hierarchy of galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Apart from its sugar-binding role, CL-L1/COLEC10 functions as a chemoattractant, suggesting potential engagement in the modulation of cell migration. CL-L1/COLEC10 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CL-L1/COLEC10 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CL-L1/COLEC10 Protein, Mouse (HEK293, Fc) is 159 a.a., with molecular weight of 53-57 kDa.

HY-P77340

	CL-L1/COLEC10 Protein, Cynomolgus (HEK293, Fc) Collectin-10; Collectin liver protein 1; CL-L1; Collectin-34; CL-34	Cynomolgus	HEK293
	CL-L1/COLEC10, operating as a lectin, displays distinct sugar-binding preferences, with a hierarchy of galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Apart from its sugar-binding role, CL-L1/COLEC10 functions as a chemoattractant, suggesting potential engagement in the modulation of cell migration. CL-L1/COLEC10 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CL-L1/COLEC10 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P77631

	CLEC12A/MICL Protein, Human (HEK293, Fc) MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2	Human	HEK293
	CLEC12A/MICL is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Human (HEK293, Fc) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC12A/MICL Protein, Human (HEK293, Fc) is 201 a.a., with molecular weight of 68-73 kDa.

HY-P77903

	CLEC12A/MICL Protein, Cynomolgus (HEK293, His) MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2	Cynomolgus	HEK293
	CLEC12A/MICL Protein is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. CLEC12A is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is 201 a.a., with molecular weight of 38-60 kDa.

HY-P77905

	CLEC12A/MICL Protein, Mouse (HEK293, His) MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2	Mouse	HEK293
	CLEC12A/MICL protein acts as a cell surface receptor, facilitating tyrosine phosphorylation of MAP kinases and modulating signaling cascades. It interacts with PTPN6 and PTPN11, key proteins in signaling pathways. CLEC12A/MICL Protein, Mouse (HEK293, His) is the recombinant mouse-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC12A/MICL Protein, Mouse (HEK293, His) is 203 a.a., with molecular weight of 30-40 kDa.

HY-P76267

	CLEC12A/MICL Protein, Human (HEK293, His) C-type lectin domain family 12 member A; CLL-1; DCAL-2; MICL; CD371	Human	HEK293
	CLEC12A/MICL (C-type lectin domain family 12 member A/myelosuppressive C-type lectin-like receptor) is a cell surface receptor that acts as a modulator of signaling cascades, specifically promoting target MAP kinases Protease. CLEC12A/MICL Protein, Human (HEK293, His) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag.

HY-P77633

	CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi) MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2	Human	HEK293
	CLEC12A/MICL is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with C-Avi, N-His labeled tag. The total length of CLEC12A/MICL Protein, Human (Biotinylated, HEK293, His-Avi) is 201 a.a., with molecular weight of 40-60 kDa.

HY-P77634

	CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi) MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2	Human	HEK293
	CLEC12A/MICL is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi) is 201 a.a., with molecular weight of 60-75 kDa.

HY-P78653

	FITC-Labeled CLEC12A/MICL Protein, Human (HEK293, His, solution) C-type lectin domain family 12 member A; CLL-1; DCAL-2; MICL; CD371	Human	HEK293
	CLEC12A/MICL (C-type lectin domain family 12 member A/myelosuppressive C-type lectin-like receptor) is a cell surface receptor that acts as a modulator of signaling cascades, specifically promoting target MAP kinases Protease. FITC-Labeled CLEC12A/MICL Protein, Human (HEK293, His, solution) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag.

HY-P703892

	CLL-1/CLEC12A Protein, Human (Biotinylated, AVI, Fc) C-type lectin domain family 12; member A	Human	HEK293

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HY-P81674

	CLEC12A Antibody (YA1419) CLEC12A; MICL; CLL-1; CLL1; DCAL2; DCAL-2; CD371	FC, ELISA	Human
	CLEC12A Antibody (YA1419) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1419), targeting CLEC12A. CLEC12A Antibody (YA1419) can be used for FC, ELISA experiment in human background.

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