CLEC12A/MICL Protein, Cynomolgus (HEK293, His)

CLEC12A/MICL Protein is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. CLEC12A is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CLEC12A/MICL protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC12A/MICL Protein, Cynomolgus (HEK293, His) is 201 a.a., with molecular weight of 38-60 kDa.

C-type lectin domain family 12 member A (CLEC12A) is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. CLEC12A is a type II transmembrane protein expressed in humans by myeloid cells, including neutrophils, monocytes, plasmacytoid BDCA2⁺, and myeloid CD1⁺c/CD19^- dendritic cells. CLEC12A is a cell surface receptor known to regulate signaling cascades and facilitate the tyrosine phosphorylation of target MAP kinases. It interacts with PTPN6 and PTPN11, indicating its involvement in intricate cellular signaling processes. In addition, CLEC12A may regulate the inflammatory response to infectious agents through direct interaction with pathogen-derived crystals or antigens. It regulates cytokine synthesis by synergizing or antagonizing signaling pathways of a variety of receptors including TLRs and the CD40 receptor in a stimulus-dependent manner. CLEC12A is also involved in adaptive immunity through its ability to internalize antigen for routing to Major Histocompatibility complex (MHC) compartments and presentation to T cells^[1][2].

Cynomolgus

HEK293

N-His

A0A2K5WXQ6 (H65-A265)

102143884  [NCBI]

38-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.