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  6. CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi)

CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi)

Cat. No.: HY-P77634
Data Sheet Handling Instructions Technical Support

CLEC12A/MICL (C-type lectin domain family 12 member A/myelosuppressive C-type lectin-like receptor) is a cell surface receptor that acts as a modulator of signaling cascades, specifically promoting target MAP kinases Protease. CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi) is 201 a.a., with molecular weight of 60-75 kDa.

For research use only. We do not sell to patients.

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Description

CLEC12A/MICL (C-type lectin domain family 12 member A/myelosuppressive C-type lectin-like receptor) is a cell surface receptor that acts as a modulator of signaling cascades, specifically promoting target MAP kinases Protease. CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi) is 201 a.a., with molecular weight of 60-75 kDa.

Background

CLEC12A/MICL (C-type lectin domain family 12 member A/Myeloid inhibitory C-type lectin-like receptor) is a cell surface receptor that functions as a regulator of signaling cascades, specifically facilitating the tyrosine phosphorylation of target MAP kinases. Through its interactions with PTPN6 and PTPN11, CLEC12A/MICL is implicated in intricate cellular signaling processes, suggesting its significance in modulating immune responses and potentially serving as a target for therapeutic interventions aimed at manipulating immune system function.

Biological Activity

Immobilized Anti-CLEC12A Antibody, hFc Tag at 1 μg/mL (100 μl/Well) on the plate. Dose response curve for Biotinylated Human CLEC12A, hFc Tag with the EC50 of 21.1 ng/mL determined by ELISA.

Species

Human

Source

HEK293

Tag

N-hFc;N-Avi

Accession

Q5QGZ9-2 (H65-A265)

Gene ID
Molecular Construction
N-term
hFc-Avi
CLEC12A (H65-A265)
Accession # Q5QGZ9-2
C-term
Synonyms
MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2
Molecular Weight

60-75 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi) Related Classifications

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
CLEC12A/MICL Protein, Human (Biotinylated, HEK293, Fc-Avi)
Cat. No.:
HY-P77634
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