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Class IB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Antibiotic (1) Apoptosis (1) Potassium Channel (1) Sodium Channel (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (1) Neurological Disease (2)

5

Inhibitors & Agonists

9

Recombinant Proteins

Targets Recommended: Scavenger Receptor Class B type I (SR-BI） Nuclear Hormone Receptor 4A/NR4A CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Aprindine hydrochloride	Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a hERG channel blocker with an IC50 of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na+/Ca2+ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

Piclidenoson Maximum Cited Publications 6 Publications Verification IB-MECA; CF-101	Adenosine Receptor Apoptosis	Inflammation/Immunology Cancer
Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19 .

Mexiletine hydrochloride 1 Publications Verification KOE-1173 hydrochloride	Sodium Channel	Cardiovascular Disease Neurological Disease
Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC₅₀ : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .

IB-96212	Antibiotic	Infection Cancer
IB-96212 (compound 5) is a member of oligomycin class which can be extracted ftom the marine Micromonospora sp. L-25-ES25-008 ref. IB-96212 is an antitumor antibiotic against P-388, it also exhibits antimicrobial activity against Micrococcus luteus .

Mexiletine hydrochloride (Standard) KOE-1173 hydrochloride (Standard)	Sodium Channel	Cardiovascular Disease Neurological Disease
Mexiletine (hydrochloride) (Standard) is the analytical standard of Mexiletine (hydrochloride). This product is intended for research and analytical applications. Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC₅₀ : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research .

Species:	Human (6) Rhesus Macaque (1) Cynomolgus (2)
Tag:	His (9) Avi (9)
Source:	HEK293 (8) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	HLA-G Complex Protein, Human (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Protein, Human (HEK293, His-Avi), has molecular weight of 51-65 kDa.

	HLA-G Protein, Human (C66S, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Human	E. coli
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Protein, Human (C66S, His-Avi) is the recombinant human-derived HLA-G protein, expressed by E. coli , with C-Avi, C-His labeled tag and C66S, , , , mutation.

	HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

	HLA-G Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G, a non-classical major histocompatibility class Ib molecule, crucially regulates immunity at the maternal-fetal interface. Partnered with B2M, it forms a complex selectively binding self-peptides, fostering maternal-fetal tolerance through interactions with KIR2DL4, LILRB1, and LILRB2 receptors. Engagement triggers NK cell senescence, induces regulatory T cell differentiation, and balances tolerance and antiviral immunity. HLA-G actively contributes to immune modulation at the maternal-fetal interface, showcasing its multifaceted role in promoting fetal development while maintaining immune balance. HLA-G Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 260-265 kDa.

	PE-Labeled HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. PE-Labeled HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. PE-Labeled HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

	HLA-G Complex Protein, Cynomolgus (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Cynomolgus	HEK293
	The HLA-A0201 WT-1 complex protein is a member of the MHC class I family and is critical for immune function, presenting antigenic peptides to cytotoxic T lymphocytes. This protein is associated with the HLA-A0201 allele and contributes to immune surveillance and defense mechanisms. HLA-G Complex Protein, Cynomolgus (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G and B2M/Beta-2 microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Protein, Cynomolgus (HEK293, His-Avi), has molecular weight of 55-65 kDa.

	HLA-G Complex Tetramer Protein, Cynomolgus (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Cynomolgus	HEK293
	The HLA-A0201 WT-1 complex protein is a member of the MHC class I family and is critical for immune function, presenting antigenic peptides to cytotoxic T lymphocytes. This protein is associated with the HLA-A0201 allele and contributes to immune surveillance and defense mechanisms. HLA-G Complex Tetramer Protein, Cynomolgus (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G and B2M/Beta-2 microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Cynomolgus (HEK293, His-Avi), has molecular weight of 260-265 kDa.

	HLA-G Complex Protein, Human (Biotinylated, HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G, a non-classical major histocompatibility class Ib molecule, crucially regulates immunity at the maternal-fetal interface. Partnered with B2M, it forms a complex selectively binding self-peptides, fostering maternal-fetal tolerance through interactions with KIR2DL4, LILRB1, and LILRB2 receptors. Engagement triggers NK cell senescence, induces regulatory T cell differentiation, and balances tolerance and antiviral immunity. HLA-G actively contributes to immune modulation at the maternal-fetal interface, showcasing its multifaceted role in promoting fetal development while maintaining immune balance. HLA-G Complex Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 51-60 kDa.

	HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC Class IB antigen; MHC-G; sHLA-G	Rhesus Macaque	HEK293
	HLA-G is part of the MHC class I family and plays a key role in immune regulation by presenting antigens to cytotoxic T cells and natural killer cells. Unlike other MHC class I molecules, it exhibits limited polymorphism and tissue-specific expression, including in immune privileged sites and the placenta. HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G and B2M/Beta-2 microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi), has molecular weight of 260-265 kDa.

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