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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

Results for "

Complement factor D

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Complement System (10)
By Research Areas:	Inflammation/Immunology (10) Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Targets Recommended: Complement System

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138281

Complement factor D-IN-2	Complement System	Inflammation/Immunology
Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. Complement factor D-IN-2 can be used for the research of autoimmune diseases .

HY-102034

Complement factor D-IN-1	Complement System	Inflammation/Immunology
Complement factor D-IN-1 is a potent and selective *small-molecule reversible factor* d inhibitor, with IC₅₀**s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.

HY-147297

Pelecopan BCX9930	Complement System	Inflammation/Immunology
Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC₅₀ value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases .

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

HY-128570

FD-IN-1	Complement System	Inflammation/Immunology
FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC₅₀ of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC₅₀s of 7.7 and 6.5 µM, respectively .

HY-122700

Factor D inhibitor 6	Complement System	Inflammation/Immunology
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC₅₀ of 30 nM and a K_d of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .

HY-117930

Danicopan 3 Publications Verification ACH-4471	Complement System	Inflammation/Immunology
Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with K_d value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .

HY-139588

Vemircopan ALXN2050; ACH 0145228; ACH-5228	Complement System	Metabolic Disease Inflammation/Immunology
Vemircopan (ALXN2050) is an orally active complement factor D inhibitor. Vemircopan is promising for research of paroxysmal nocturnal hemoglobinuria .

HY-P2830

Complement factor D	Others	Others
Complement factor D is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W049802

N-((Allyloxy)carbonyl)-N-methyl-L-alanine	Complement System	Inflammation/Immunology
N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. N-((Allyloxy)carbonyl)-N-methyl-L-alanine can be used for the synthesis of inhibitors of complement factor D. Complement factor D inhibitors can be used in the research of immune system related disease .

HY-163684

Zoracopan	Complement System	Inflammation/Immunology
Zoracopan is a selective complement factor D (CFD) inhibitor. When administered systemically (orally or intravenously), Zoracopan accumulates and is sustained-released in ocular tissues, primarily in the choroid-retinal pigment epithelium (C-RPE) and/or iridociliary body (I-CB) .

Cat. No.	Product Name	Target	Research Area

HY-W049802

N-((Allyloxy)carbonyl)-N-methyl-L-alanine	Complement System	Inflammation/Immunology
N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. N-((Allyloxy)carbonyl)-N-methyl-L-alanine can be used for the synthesis of inhibitors of complement factor D. Complement factor D inhibitors can be used in the research of immune system related disease .

Cat. No.	Product Name	Target	Research Area

HY-P99298

Lampalizumab RG 7417; TNX 234; Anti-CFD Recombinant Antibody	Complement System	Inflammation/Immunology
Lampalizumab (RG 7417) is a humanised monoclonal antibody targeting complement Factor D in the alternative complement pathway. Lampalizumab binds an exosite and sterically blocks Factor B access to the active site. Lampalizumab can be used for age-related macular degeneration (AMD) research .

Species:	Human (3) Rhesus Macaque (1) Mouse (2) Rat (1)
Tag:	His (5) Fc (2)
Source:	HEK293 (6) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7861

	Complement Factor D/Adipsin Protein, Human (HEK293, His) rHuComplement factor D/Adipsin, His; Complement factor D; CFD; Adipsin; C3 convertase activator; Properdin factor D; DF; PFD	Human	HEK293
	Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, His) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Human (HEK293, His) is 228 a.a., with molecular weight of ~28.0 kDa.

HY-P7876

	Complement Factor D/Adipsin Protein, Mouse (HEK293, His) rMuComplement factor D/Adipsin, His; Complement factor D; 28 kDa adipocyte protein; Adipsin; C3 convertase activator; Properdin factor D; Cfd; Adn; Df	Mouse	HEK293
	Complement Factor D/Adipsin Protein cleaves factor B in complex with factor C3b, activating the C3bbb complex to form the C3 convertase in the alternate pathway, analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71726

	Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) Cfd; Adn; Df; Complement factor D; EC 3.4.21.46; Adipsin; C3 convertase activator; Endogenous vascular elastase; Properdin factor D	Rat	P. pastoris
	Complement Factor D/Adipsin Protein is pivotal, cleaving factor B within the factor C3b complex to activate the C3bbb complex, serving as the C3 convertase in the alternate pathway—analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) is the recombinant rat-derived Complement Factor D/Adipsin protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) is 238 a.a., with molecular weight (glycosylation form) of ~43 kDa.

HY-P7861A

	Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution) rHuComplement factor D/Adipsin, His; Complement factor D; CFD; Adipsin; C3 convertase activator; Properdin factor D; DF; PFD	Human	HEK293
	Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Complement Factor D/Adipsin Protein, Human (HEK293, His, Solution) is 228 a.a., with molecular weight of ~28.0 kDa.

HY-P78273

	Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) Adipsin; C3 convertase activator; Complement factor D; CFD; PFD; DF; ADN; factor D; AMBP-1; EC 3.4.21; EC 3.4.21.46	Mouse	HEK293
	Complement Factor D/Adipsin Protein cleaves factor B in complex with factor C3b, activating the C3bbb complex to form the C3 convertase in the alternate pathway, analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78545

	Complement Factor D/Adipsin Protein, Human (HEK293, Fc) Adipsin; C3 convertase activator; Complement factor D; CFD; PFD; DF; ADN; factor D; AMBP-1; EC 3.4.21; EC 3.4.21.46	Human	HEK293
	Complement factor D, also known as Adipsin, plays a crucial role in the alternative pathway of the complement system and when complexed with factor C3b, it cleaves factor B. This cleavage activates the C3bbb complex, converting it to the C3 convertase of the alternative pathway. Complement Factor D/Adipsin Protein, Human (HEK293, Fc) is the recombinant human-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Complement Factor D/Adipsin Protein, Human (HEK293, Fc) is 228 a.a., with molecular weight of 52-60 kDa.

HY-P77898

	Complement Factor D/Adipsin Protein, Rhesus macaque (HEK293, His) Adipsin; C3 convertase activator; Complement factor D; CFD; PFD; DF; ADN; factor D; AMBP-1; EC 3.4.21; EC 3.4.21.46	Rhesus Macaque	HEK293
	Complement Factor D/Adipsin Protein is a member of the S1, or chymotrypsin, family of serine peptidases. Complement Factor D is expressed by adipose cells, plays an important role in both physiology and pathophysiology, where it plays a regulatory role in the complement system. Complement Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Complement Factor D/Adipsin Protein, Rhesus macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-His labeled tag. The total length of Complement Factor D/Adipsin Protein, Rhesus macaque (HEK293, His) is 233 a.a., with molecular weight of 70-80 kDa.

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