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Pathways Recommended:	Cell Cycle/DNA Damage

Results for "

DNA Ligase IV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (4) Apoptosis (3) CRISPR/Cas9 (2)
By Research Areas:	Cancer (4)

4

Inhibitors & Agonists

1

Antibodies

Targets Recommended: DNA-PK DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis Ligands for E3 Ligase E3 Ligase Ligand-Linker Conjugates Glucokinase E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

L189 3 Publications Verification	DNA/RNA Synthesis	Cancer
L189 is a **DNA ligase** inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC₅₀ values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer .

SCR130	DNA/RNA Synthesis Apoptosis	Cancer
SCR130 is a SCR7-based DNA nonhomologous end-joining (NHEJ) inhibitor. SCR130 inhibits the end-joining of DNA in a Ligase IV-dependent manner. SCR130 is specific to Ligase IV, and shows minimal or no effect on Ligase III and Ligase I mediated joining. SCR130 induces cell apoptosis and has anticancer activity .

SCR7 pyrazine Maximum Cited Publications 11 Publications Verification	CRISPR/Cas9 DNA/RNA Synthesis Apoptosis	Cancer
SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .

SCR7	DNA/RNA Synthesis CRISPR/Cas9 Apoptosis	Cancer
SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine (HY-107845). SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .

Cat. No.	Compare	Product Name	Application	Reactivity

	DNA Ligase IV Antibody (YA2699) LIG4; DNA Ligase 4; DNA Ligase IV; Polydeoxyribonucleotide synthase [ATP] 4	WB	Human
	DNA Ligase IV Antibody (YA2699) is a biotin-conjugated non-conjugated IgG antibody, targeting DNA Ligase IV, with a predicted molecular weight of 104 kDa (observed band size: 104 kDa). DNA Ligase IV Antibody (YA2699) can be used for WB experiment in human background.

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