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Isoforms Recommended:	DP

Results for "

DP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Bacterial (1) Endogenous Metabolite (2) Prostaglandin Receptor (16)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (10) Inflammation/Immunology (13) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15342

Timapiprant 3 Publications Verification OC000459	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP₂, also known as *CRTH2) antagonist. Timapiprant (OC000459) potently displaces [ ³H] PGD2 from human recombinant DP₂* (K_i=13 nM), rat recombinant DP₂ (K_i=3 nM), and human native DP₂ (K_i=4 nM). Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils .

HY-15342A

Timapiprant sodium 3 Publications Verification OC000459 sodium	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Timapiprant sodium (OC000459 sodium) is a potent, selective, and orally active D prostanoid receptor 2 (DP₂, also known as *CRTH2) antagonist. Timapiprant sodium (OC000459 sodium) potently displaces [ ³H] PGD2 from human recombinant DP₂* (K_i=13 nM), rat recombinant DP₂ (K_i=3 nM), and human native DP₂ (K_i=4 nM). Timapiprant sodium (OC000459 sodium) inhibits mast cell activation of Th2 lymphocytes and eosinophils .

HY-13213

AM211 AM211 free acid	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC₅₀s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.

HY-109186

Pexopiprant	Prostaglandin Receptor	Others
Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),K_i ＜ 100nM. Pexopiprant can be used in studies of asthma .

HY-15950

AZD1981 2 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
AZD1981 is a potent and selective CRTh2 antagonist; displaces radio-labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8.4).

HY-U00423

CRTH2-IN-1 Ramatroban analog	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
CRTH2-IN-1 (Ramatroban analog) is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist with an IC₅₀ of 6 nM in a human DP2 binding assay.

HY-118180

CAY10595	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
CAY10595 is a potent *CRTH2/DP2* receptor antagonist that binds to the human receptor with a K_i of 10 nM.

HY-13213A

AM211 sodium	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
AM211 sodium is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC₅₀s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.

HY-118830

13,14-Dihydro-15-keto prostaglandin D2 DK-PGD2; 15-Oxo-13,14-dihydro-PGD2; 13,14-Dihydro-15-keto-PGD2	Prostaglandin Receptor	Endocrinology
13, 14-Dihydro-15-keto prostaglandin D2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandin D2 is a selective agonist for the *DP2* receptor. 13, 14-Dihydro-15-keto prostaglandin D2 can inhibit ion flux in canine colonic mucosa preparation .

HY-137308

15(R)-Prostaglandin D2 15R-PGD2	Prostaglandin Receptor	Inflammation/Immunology
15(R)-Prostaglandin D2 is a potential prostatic hormone DP(2) receptor (Prostaglandin Receptor) agonist with anti-inflammatory activity. 15(R)-Prostaglandin D2 increases actin polymerization in human eosinophils and increases cAMP levels in platelets .

HY-117862

TASP0412098	Prostaglandin Receptor	Inflammation/Immunology
TASP0412098 is an orally available, potent and selective *CRTH2/DP2* antagonist with high binding affinity (IC50 2.1 nM) and functional activity (IC50 12 nM). TASP0412098 has the potential to suppress asthma in mouse and guinea pig bronchial asthma models .

HY-16768

Fevipiprant 1 Publications Verification QAW039; NVP-QAW039	Prostaglandin Receptor	Cardiovascular Disease
Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible *prostaglandin D2 (DP2) receptor* antagonist with an K_d value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma ^[2] .

HY-116890

CRTh2 antagonist 4	Others	Inflammation/Immunology
CRTh2 antagonist 4 (compound 58) is an inhibitor (IC₅₀: 212 nM) of TH2 lymphocyte (CRTH2 or *DP2*) receptor with high binding affinity (Ki= 37 nM). CRTh2 antagonist 4 can be used in the study of severe allergic diseases .

HY-P4096

HAP-1	Bacterial	Inflammation/Immunology
HAP-1 is a synovial-targeted transduction peptide. HAP-1 facilitates specific internalization of protein complexes into human and rabbit synovial cells. HAP-1 fused to an antimicrobial peptide, (KLAK)₂, to generate a proapoptotic peptide DP2 .

HY-114141

BI-671800	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells *(DP2/CRTH2), with IC₅₀* values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively . BI-671800 has potential for the treatment of poorly controlled asthma ^[2].

HY-14973

Vidupiprant AMG 853	Prostaglandin Receptor	Inflammation/Immunology
Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC₅₀s of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment .

HY-125782

15(R)-15-Methyl prostaglandin D2 15(R)-15-Methyl PGD2	Prostaglandin Receptor	Metabolic Disease
15(R)-15-Methyl prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC₅₀ values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC₅₀ for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.

HY-126911

11-keto Fluprostenol Fluprostenol Prostaglandin D2	Prostaglandin Receptor	Endocrinology
11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.

HY-116028

15-deoxy-Δ12,14-Prostaglandin D2 15-Deoxy-Δ12,14-PGD2	Endogenous Metabolite	Cardiovascular Disease
15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2. It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki=50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC₅₀=8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM.1 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC₅₀=0.3 μg/mL). It inhibits ADP-induced platelet aggregation (IC₅₀=320 ng/ml) less potently than PGD2.

HY-E70316

Chimax-O Endo-chitosanase	Endogenous Metabolite	Others
Chimax-O (Endo-chitosanase) is an endochitosanase belonging to the GH46 family that catalyzes chitosan substrate to produce chitobiose and D-glucosamine (GlcN). Chimax-O acts in a stochastic intra-action manner, producing chitosan derivatives with different degrees of polymerization (DP) ≤2 .

HY-A0095

Flibanserin 2 Publications Verification BIMT-17; BIMT-17BS	5-HT Receptor	Neurological Disease Cancer
Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^- .

HY-A0095A

Flibanserin hydrochloride (propan-2-ol) hydrate 2 Publications Verification BIMT-17 hydrochloride (propan-2-ol) hydrate; BIMT-17BS hydrochloride (propan-2-ol) hydrate	5-HT Receptor	Neurological Disease Cancer
Flibanserin (hydrochloride) (propan-2-ol) (hydrate) (BIMT-17 (hydrochloride) (propan-2-ol) (hydrate); BIMT-17BS (hydrochloride) (propan-2-ol) (hydrate))is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^- .

HY-A0095R

Flibanserin (Standard)	5-HT Receptor	Neurological Disease Cancer
Flibanserin (Standard) is the analytical standard of Flibanserin. This product is intended for research and analytical applications. Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^- .

Cat. No.	Product Name	Target	Research Area

HY-P4096

HAP-1	Bacterial	Inflammation/Immunology
HAP-1 is a synovial-targeted transduction peptide. HAP-1 facilitates specific internalization of protein complexes into human and rabbit synovial cells. HAP-1 fused to an antimicrobial peptide, (KLAK)₂, to generate a proapoptotic peptide DP2 .

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