1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. Flibanserin hydrochloride (propan-2-ol) hydrate

Flibanserin hydrochloride (propan-2-ol) hydrate  (Synonyms: BIMT-17 hydrochloride (propan-2-ol) hydrate; BIMT-17BS hydrochloride (propan-2-ol) hydrate)

Cat. No.: HY-A0095A Purity: 98.90%
COA Handling Instructions

Flibanserin (hydrochloride) (propan-2-ol) (hydrate) (BIMT-17 (hydrochloride) (propan-2-ol) (hydrate); BIMT-17BS (hydrochloride) (propan-2-ol) (hydrate))is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-.

For research use only. We do not sell to patients.

Flibanserin hydrochloride (propan-2-ol) hydrate Chemical Structure

Flibanserin hydrochloride (propan-2-ol) hydrate Chemical Structure

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Based on 2 publication(s) in Google Scholar

Other Forms of Flibanserin hydrochloride (propan-2-ol) hydrate:

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2 Publications Citing Use of MCE Flibanserin hydrochloride (propan-2-ol) hydrate

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  • Purity & Documentation

  • References

  • Customer Review

Description

Flibanserin (hydrochloride) (propan-2-ol) (hydrate) (BIMT-17 (hydrochloride) (propan-2-ol) (hydrate); BIMT-17BS (hydrochloride) (propan-2-ol) (hydrate))is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].

IC50 & Target

5-HT1A Receptor

1 nM (Ki)

5-HT2A Receptor

49 nM (Ki)

In Vitro

Flibanserin (hydrochloride) (propan-2-ol) (hydrate) (0.01-100 μM; 72 h) can transform into two degradation products DP1 and DP2 with no toxicity potential after oxidative degradation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NHSF cell lin
Concentration: 0.01, 0.1, 1, 10, 100 μM
Incubation Time: 72 hours
Result: Resulted cell viability reached to 97.91% (DP1) and 96.73% (DP2) at 0.01 μM.
Showed non-toxic up to 100 μM (IC50 >100 μM).
In Vivo

Flibanserin hydrochloride (1, 10, 30 mg/kg; i.p.; single dose) shows different pharmacological properties in prefrontal cortex, hippocampus and midbrain. The 5-HT1A receptor occupancy in cortex indicates it’s the more sensitive than other brain region[2].
Flibanserin hydrochloride (15, 45 mg/kg; p.o.; twice a day; 22 d) preferentially activates the brain regions belonging to the mesolimbic dopaminergic pathway and hypothalamic structures involved in the integration of sexual cues related to sexual motivation[3].
Flibanserin hydrochloride (5, 10, 25, and 50 mg/kg; s.c.; single dose) has anxiolytic effects without locomotor side effects in rat ultrasonic vocalization model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Long Evans female rats (225-250 g)[3]
Dosage: 15 mg/kg; 45 mg/kg
Administration: Oral gavage; twice a day for 22 days
Result: Increased the density of activated catecholaminergic neurons in the ventral tegmental area but not in the locus coeruleus.
Increased Fos expression in the medial preoptic area and arcuate nucleus of the hypothalamus, ventral tegmental area, locus coeruleus, and lateral paragigantocellular nucleus with chronic 22-day treatment.
Animal Model: Rat pup ultrasonic vocalization model of anxiety[4]
Dosage: 5, 10, 25, and 50 mg/kg
Administration: Subcutaneous injection
Result: Reduced ultrasonic vocalizations in rat pups.
Showed effective within 30 min and has no severe locomotor side effects at active doses.
Clinical Trial
Molecular Weight

465.20

Formula

C20H22ClF3N4O.0.5C3H8O.0.5H2O

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(N1CCN3CCN(CC3)C4=CC=CC(C(F)(F)F)=C4)C=CC=C2.CC(O)C.Cl.[0.5].O.[0.5]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.04%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Flibanserin hydrochloride (propan-2-ol) hydrate
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