2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 15-deoxy-Δ12,14-Prostaglandin D2

15-deoxy-Δ12,14-Prostaglandin D2  (Synonyms: 15-Deoxy-Δ12,14-PGD2)

Cat. No.: HY-116028 Purity: ≥98.0%
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15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2. It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki=50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50=8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM.1 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/mL). It inhibits ADP-induced platelet aggregation (IC50=320 ng/ml) less potently than PGD2.

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15-deoxy-Δ12,14-Prostaglandin D2 Chemical Structure

15-deoxy-Δ12,14-Prostaglandin D2 Chemical Structure

CAS No. : 85235-11-6

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1 mg (2.99 mM * 1 mL in Methyl acetate) USD 735 In-stock
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15-deoxy-Δ12,14-Prostaglandin D2 Related Antibodies

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Description

15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2. It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki=50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50=8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM.1 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/mL). It inhibits ADP-induced platelet aggregation (IC50=320 ng/ml) less potently than PGD2.

Molecular Weight

334.45

Formula

C20H30O4
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C1/C([C@H]([C@H](C1)O)C/C=C\CCCC(O)=O)=C/C=C/CCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥98.0%

SDS (394 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References
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15-deoxy-Δ12,14-Prostaglandin D2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

15-deoxy-Δ12,14-Prostaglandin D285235-11-615-Deoxy-Δ12,14-PGD2Endogenous MetaboliteInhibitorinhibitorinhibit

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