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Results for "

Dolastatin-10

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (9) Amino Acid Derivatives (1) Apoptosis (3) Drug-Linker Conjugates for ADC (3) Microtubule/Tubulin (13)
By Research Areas:	Cancer (24)
Click Chemistry:	DBCO (1) Azide (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Neprilysin Apical Sodium-Dependent Bile Acid Transporter

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15580

*Dolastatin 10* DLS 10; NSC 376128	Microtubule/Tubulin ADC Cytotoxin	Cancer
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

HY-15581

MMAD DemethylDolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10	Microtubule/Tubulin ADC Cytotoxin	Cancer
MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).

HY-78828A

(S)-Dolaphenine hydrochloride	Microtubule/Tubulin	Others Cancer
(S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization .

HY-33046

N-Boc-dolaproine (2R,3R)-BOC-dolaproine	Others	Cancer
N-Boc-dolaproine (Dap) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-43304

N-Boc-dolaproine-methyl	Others	Cancer
N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-42912A

N-Boc-dolaproine-OH dicyclohexylamine	Others	Cancer
N-Boc-dolaproine-OH dicyclohexylamine is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-33046A

N-Boc-dolaproine dicyclohexylamine (2R,3R)-BOC-dolaproine dicyclohexylamine	Others	Cancer
N-Boc-dolaproine dicyclohexylamine is an amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity. And contains dicyclohexylamine .

HY-126492

Vat-Cit-PAB-Monomethyl Dolastatin 10	Drug-Linker Conjugates for ADC	Cancer
Vat-Cit-PAB-Monomethyl Dolastatin 10 is a agent-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.

HY-128894

MC-Sq-Cit-PAB-Dolastatin10	Drug-Linker Conjugates for ADC	Cancer
MC-Sq-Cit-PAB-Dolastatin10 is a agent-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB.

HY-42912

N-Boc-dolaproine-OH ((+)-phenylethylamine)	Others	Cancer
N-Boc-dolaproine-OH ((+)-phenylethylamine) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-49053

N-Boc-dolaproine-amide-Me-Phe	Others	Cancer
N-Boc-dolaproine-amide-Me-Phe is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-78932C

(2S,3R)-Dap-NE hydrochloride	Others	Cancer
(2S,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-78932D

(2R,3R)-Dap-NE hydrochloride	Others	Cancer
(2R,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-139625

Dolastatinol	Microtubule/Tubulin	Cancer
Dolastatinol is a synthetic analog of dolastatin 10 and low nanomolar inhibitor of tubulin polymerization.

HY-14672

Soblidotin 1 Publications Verification Auristatin PE; TZT-1027	Microtubule/Tubulin	Cancer
Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization.

HY-125453

Symplostatin 1	Others	Cancer
Symplostatin 1 is a Dolastatin 10 (HY-15580) analogue that can be isolated from the marine cyanobacterium Symploca hydnoides .

HY-12522S

PF-06380101-d8 2 Publications Verification Aur0101-d₈; Auristatin-0101-d₈	Microtubule/Tubulin ADC Cytotoxin	Cancer
PF-06380101-d₈ is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue[1].

HY-78927

N-Boc-L-Prolinal	Amino Acid Derivatives	Others
N-Boc-L-Prolinal is a proline with a Boc protecting group, which can be used to synthesize biologically active peptide mimetics, such as the synthesis of Dolastatin 10 (HY-15580) analogs with anti-colon cancer activity .

HY-15162

Monomethyl auristatin E Maximum Cited Publications 40 Publications Verification MMAE; SGD-1010; Vedotin	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

HY-12522

PF-06380101 Aur0101; Auristatin-0101	Microtubule/Tubulin ADC Cytotoxin	Cancer
PF-06380101 (Aur0101), an auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue. PF-06380101 (Aur0101) shows excellent potencies in tumor cell proliferation assays and differential ADME properties when compared to other synthetic auristatin analogues that are used in the preparation of ADCs.

HY-P1126

Dolastatin 15 DLS 15	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin .

HY-15162R

Monomethyl auristatin E (Standard) MMAE (Standard); SGD-1010 (Standard); Vedotin (Standard)	Microtubule/Tubulin Apoptosis	Cancer
Monomethyl auristatin E (MMAE) (Standard) is the analytical standard of Monomethyl auristatin E (HY-15162). This product is intended for research and analytical applications. Monomethyl auristatin E is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) against several different cancer types .

HY-15582

Auristatin E	Microtubule/Tubulin ADC Cytotoxin	Cancer
Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids .

HY-144585

AGD-0182	Microtubule/Tubulin ADC Cytotoxin	Others
AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10 . AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-15581S

MMAD-d8 DemethylDolastatin 10-d₈; Monomethylauristatin D-d₈; Monomethyl Dolastatin 10-d₈	ADC Cytotoxin Microtubule/Tubulin	Cancer
MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

HY-136314

DBCO-PEG4-VC-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. DBCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Cat. No.	Product Name	Target	Research Area

HY-15580

*Dolastatin 10* DLS 10; NSC 376128	Microtubule/Tubulin ADC Cytotoxin	Cancer
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

HY-78927

N-Boc-L-Prolinal	Amino Acid Derivatives	Others
N-Boc-L-Prolinal is a proline with a Boc protecting group, which can be used to synthesize biologically active peptide mimetics, such as the synthesis of Dolastatin 10 (HY-15580) analogs with anti-colon cancer activity .

HY-P1126

Dolastatin 15 DLS 15	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Dolastatin 15 (DLS 15), a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the antitubulin agent Dolastatin 10. Dolastatin 15 induces cell cycle arrest and apoptosis in multiple myeloma cells. Dolastatin 15 can be used as an ADC cytotoxin .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15580

*Dolastatin 10* DLS 10; NSC 376128	Structural Classification Natural Products Classification of Application Fields Source classification Marine natural products Other marine organisms Disease Research Fields Cancer	Microtubule/Tubulin ADC Cytotoxin
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

HY-78828A

(S)-Dolaphenine hydrochloride	Classification of Application Fields Disease Research Fields Cancer	Microtubule/Tubulin
(S)-Dolaphenine hydrochloride is a component of Dolastatin 10 (HY-15580). Dolastatin 10, an antineoplastic agent, inhibits tubulin polymerization .

HY-125453

Symplostatin 1	Structural Classification Natural Products Microorganisms Source classification	Others
Symplostatin 1 is a Dolastatin 10 (HY-15580) analogue that can be isolated from the marine cyanobacterium Symploca hydnoides .

Cat. No.	Product Name	Chemical Structure

HY-12522S

PF-06380101-d8 2 Publications Verification
PF-06380101-d₈ is a deuterium labeled PF-06380101. PF-06380101, an Auristatin microtubule inhibitor, is a cytotoxic Dolastatin 10 analogue[1].

HY-15581S

MMAD-d8
MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

Cat. No.	Product Name		Classification

HY-136314

DBCO-PEG4-VC-PAB-MMAE		DBCO
DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. DBCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-144585

AGD-0182		Azide
AGD-0182 is a microtubule disrupting agent. AGD-0182 is a synthetic analogue of the naturally occurring tubulin-binding molecule Dolastatin 10 . AGD-0182 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Dolastatin-10

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products