2. Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
  3. Microtubule/Tubulin ADC Cytotoxin
  4. Auristatin E

Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids.

For research use only. We do not sell to patients.

Auristatin E Chemical Structure

Auristatin E Chemical Structure

CAS No. : 160800-57-7

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Based on 1 publication(s) in Google Scholar

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Auristatin E Related Antibodies

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Description

Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids[1][2][3].

IC50 & Target

Auristatin

 

In Vitro

Auristatin E (1-10000 nM, 2 h) shows the cytotoxic effects on L2987 human lung adenocarcinoma cells and various hematologic cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Auristatin E Related Antibodies
In Vivo

Auristatin E (0.25 mg/kg, s.c., a single dose for 80 days) inhibits tumor growth in nude mice with subcutaneous L2987 human lung adenocarcinoma or 3396 human breast carcinoma xenografts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with subcutaneous L2987 human lung adenocarcinoma or 3396 human breast carcinoma xenografts[2]
Dosage: 0.25 mg/kg
Administration: s.c., a single dose for 80 days
Result: Showed median tumor volume when nude mice with subcutaneous L2987 human lung adenocarcinoma or 3396 human breast carcinoma xenografts were injected with conjugates or drug.
Molecular Weight

732.01

Formula

C40H69N5O7
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (136.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3661 mL 6.8305 mL 13.6610 mL
5 mM 0.2732 mL 1.3661 mL 2.7322 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

COA (252 KB) HNMR (271 KB) RP-HPLC (267 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3661 mL 6.8305 mL 13.6610 mL 34.1525 mL
5 mM 0.2732 mL 1.3661 mL 2.7322 mL 6.8305 mL
10 mM 0.1366 mL 0.6831 mL 1.3661 mL 3.4153 mL
15 mM 0.0911 mL 0.4554 mL 0.9107 mL 2.2768 mL
20 mM 0.0683 mL 0.3415 mL 0.6831 mL 1.7076 mL
25 mM 0.0546 mL 0.2732 mL 0.5464 mL 1.3661 mL
30 mM 0.0455 mL 0.2277 mL 0.4554 mL 1.1384 mL
40 mM 0.0342 mL 0.1708 mL 0.3415 mL 0.8538 mL
50 mM 0.0273 mL 0.1366 mL 0.2732 mL 0.6831 mL
60 mM 0.0228 mL 0.1138 mL 0.2277 mL 0.5692 mL
80 mM 0.0171 mL 0.0854 mL 0.1708 mL 0.4269 mL
100 mM 0.0137 mL 0.0683 mL 0.1366 mL 0.3415 mL
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Auristatin E Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Auristatin E160800-57-7Microtubule/TubulinADC CytotoxinADC Payloadcytotoxicantitumor activityADCapoptosisxenograft mouse modelsB-cell malignanciesInhibitorinhibitorinhibit

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