2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. ADC Cytotoxin Microtubule/Tubulin
  4. MMAD-d8

MMAD-d8  (Synonyms: Demethyldolastatin 10-d8; Monomethylauristatin D-d8; Monomethyl Dolastatin 10-d8)

Cat. No.: HY-15581S Purity: 98.95%
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MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.

For research use only. We do not sell to patients.

MMAD-d<sub>8</sub> Chemical Structure

MMAD-d8 Chemical Structure

Size Price Stock Quantity
1 mg USD 1056 In-stock
5 mg USD 2400 In-stock
10 mg USD 3850 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MMAD-d8:

MMAD-d8 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MMAD-d8D is a deuterated form of MMAD, which is a microtubule disrupting agent.

IC50 & Target

Auristatin

 

In Vitro

MMAD (Monomethyl Dolastatin 10) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MMAD-d8 Related Antibodies
In Vivo

The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

779.11

Formula

C41H58D8N6O6S
Unlabeled CAS

203849-91-6
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@@H](OC)[C@H]3N(C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC([C@H](C(C)C)NC)=O)=O)C)=O)CCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (128.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2835 mL 6.4176 mL 12.8352 mL
5 mM 0.2567 mL 1.2835 mL 2.5670 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2835 mL 6.4176 mL 12.8352 mL 32.0879 mL
5 mM 0.2567 mL 1.2835 mL 2.5670 mL 6.4176 mL
10 mM 0.1284 mL 0.6418 mL 1.2835 mL 3.2088 mL
15 mM 0.0856 mL 0.4278 mL 0.8557 mL 2.1392 mL
20 mM 0.0642 mL 0.3209 mL 0.6418 mL 1.6044 mL
25 mM 0.0513 mL 0.2567 mL 0.5134 mL 1.2835 mL
30 mM 0.0428 mL 0.2139 mL 0.4278 mL 1.0696 mL
40 mM 0.0321 mL 0.1604 mL 0.3209 mL 0.8022 mL
50 mM 0.0257 mL 0.1284 mL 0.2567 mL 0.6418 mL
60 mM 0.0214 mL 0.1070 mL 0.2139 mL 0.5348 mL
80 mM 0.0160 mL 0.0802 mL 0.1604 mL 0.4011 mL
100 mM 0.0128 mL 0.0642 mL 0.1284 mL 0.3209 mL
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MMAD-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMAD-d8Demethyldolastatin 10-d8Monomethylauristatin D-d8Monomethyl Dolastatin 10-d8ADC CytotoxinMicrotubule/TubulinADC PayloadInhibitorinhibitorinhibit

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