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Results for "

FEN1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

2

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122695
    FEN1-IN-2
    1 Publications Verification

    		 FLAP Cancer
    FEN1-IN-2 (compound 20) is a flap endonuclease 1 (FEN1) inhibitor, with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively [1].
    FEN1-IN-2
  • HY-123834
    FEN1-IN-1
    5 Publications Verification

    		 FLAP ATM/ATR Cancer
    FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg 2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers [1].
    FEN1-IN-1
  • HY-145758
    FEN1-IN-SC13
    1 Publications Verification

    		 Endonuclease Cancer
    FEN1-IN-SC13 is a potent DNA fragmentation endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-SC13 interferes with DNA replication and repair in vitro and in cells [1].
    FEN1-IN-SC13
  • HY-153790
    FEN1-IN-5

    		FLAP Cancer
    FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=12 nM), involving in DNA repair [1].
    FEN1-IN-5
  • HY-136484
    FEN1-IN-3

    		FLAP Cancer
    FEN1-IN-3 (Compound 4) is a human flap endonuclease-1 (hFEN1) inhibitor. FEN1-IN-3 stabilizes hFEN1 with an EC50 of 6.8 μM [1].
    FEN1-IN-3
  • HY-136485
    FEN1-IN-4
    1 Publications Verification

    		 FLAP Cancer
    FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor [1].
    FEN1-IN-4
  • HY-RS04861
    FEN1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FEN1 Human Pre-designed siRNA Set A contains three designed siRNAs for FEN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FEN1 Human Pre-designed siRNA Set A
    FEN1 Human Pre-designed siRNA Set A
  • HY-153792
    FEN1-IN-7

    		FLAP Cancer
    FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents [1].
    FEN1-IN-7
  • HY-153791
    FEN1-IN-6

    		FLAP Cancer
    FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM [1].
    FEN1-IN-6

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