2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Endonuclease

Endonuclease

Endonuclease

Endonucleases are a class of enzymes that can cleave phosphodiester bonds within nucleic acid molecules. According to the substrates they act on, endonucleases can be classified into DNA endonucleases and RNA endonucleases. According to their structural and functional characteristics, endonucleases can be divided into restriction endonucleases, non-specific endonucleases, and site-specific endonucleases. Endonucleases play an important role in the fields of DNA repair, RNA processing, and genetic engineering. Mutations in the genes encoding endonucleases can lead to genetic diseases, such as xeroderma pigmentosum. Abnormal expression or altered activity of endonucleases may promote tumorigenesis, be involved in the pathological processes of neurodegenerative diseases, and at the same time, endonucleases are also potential targets for the treatment of diseases such as tumors[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-116770
    PFM01
    		Inhibitor 99.91%
    PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).
    PFM01
  • HY-145758
    FEN1-IN-SC13
    		Inhibitor 98.21%
    FEN1-IN-SC13 is a potent DNA fragmentation endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-SC13 interferes with DNA replication and repair in vitro and in cells.
    FEN1-IN-SC13
  • HY-120951
    PFM39
    		Inhibitor 99.01%
    PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity.
    PFM39
  • HY-148078
    PFM03
    		Inhibitor 98.04%
    PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ).
    PFM03
  • HY-P2863
    Deoxyribonuclease II
    		Inhibitor
    Deoxyribonuclease II (DNase II) is an endonuclease that hydrolyzes the phosphodiester bonds of deoxyribonucleotides in native and denatured DNA, producing 3' phosphate and 5'-hydroxyl termini. Deoxyribonuclease II works best at acidic pH and is commonly used in biochemical research.
    Deoxyribonuclease II
  • HY-170844
    MU147
    		Inhibitor
    MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer activity, which is lethal to Ehrlich ascites tumor cells both in vitro and in vivo. MU147 also eliminates the double-strand break repair mechanism dependent on the MRE11 nuclease activity without impairing the activation of ATM. MU147 also impairs the degradation of nascent strands of stalled replication FOX and selectively affects brca2-deficient cells.
    MU147
  • HY-170845
    MU1409
    		Inhibitor
    MU1409 is an inhibitor of MRE11 nuclease with an IC50 of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC50 values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers.
    MU1409
  • HY-108882A
    Recombinant DNase I (RNase-free)
    Recombinant DNase I (RNase-free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I is essential for limiting inflammatory responses and maintaining homeostasis.
    Recombinant DNase I (RNase-free)
  • HY-163699
    MUS81-IN-1
    		Inhibitor 99.42%
    MUS81-IN-1 (compound 23) is a MUS81 inhibitor. MUS81-IN-1 can be used in cancer research.
    MUS81-IN-1
  • HY-157329
    AD16
    		Inhibitor
    AD16 (Acetamide) is a LINE-1 retrotransposon endonuclease inhibitor with the IC50 of 4.7 μM. AD16 (Acetamide) reduce LINE-1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells.
    AD16
  • HY-108858
    Dornase alfa
    Dornase alfa (rhDNase) is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions. Dornase alfa plays an important role in cystic fibrosis.
    Dornase alfa
  • HY-137721
    Cyclic tri-AMP
    		Activator
    Cyclic tri-AMP is a component of the cyclic oligonucleotide-based anti-phage signaling system (CBASS), and acts as the second messenger in the immune response against viral infection. Cyclic tri-AMP binds to and activates DNA endonuclease NucC, results in cell death and exhibits antiviral activity.
    Cyclic tri-AMP
  • HY-E70381
    dsDNase
    dsDNase is a highly specific double-strand DNA (dsDNA) endonuclease that quickly and efficiently removes contaminating DNA from PCR master mixes.
    dsDNase
  • HY-146125
    CGCG/CGG ligand 1
    		Inhibitor
    CGCG/CGG ligand 1 (compound 10), an anthracenone derivative, is a CGCG or CGG short spacer-ligand. CGCG/CGG ligand 1 can protect cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme.
    CGCG/CGG ligand 1
Cat. No. Product Name / Synonyms Application Reactivity